MTOR inhibitor

Product Name: MTOR inhibitor
CAS No.: 1207358-59-5
Chemical Name: MTOR inhibitor
Synonyms: MTOR-IN-1;MTOR inhibitor;mTOR inhibitor-3;GDC-mTOR inhibitor;mTOR inhibitor (mTOR-IN-1);mTOR inhibitor-3, 10 mM in DMSO;Inhibitor,inhibit,mTOR,mTOR inhibitor 3,mTOR inhibitor-3,mTOR inhibitor3,Mammalian target of Rapamycin;N-Ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea;Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]-
CBNumber: CB52666665
Molecular Formula: C25H30N8O2
Formula Weight: 474.56
MOL File: 1207358-59-5.mol

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MTOR inhibitor Property

Density: 1.277±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (105.36 mM; Need ultrasonic)
form: Powder
pka: 13.87±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1383
Product name: mTORinhibitor-3
Purity: 98.54%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-1383
Product name: mTORinhibitor-3
Purity: 98.54%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

ApexBio Technology

Product number: A3637
Product name: GDC-mTORinhibitor
Packaging: 5mg
Price: $381
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611741
Product name: mTOR-IN-1
Packaging: 10mg
Price: $547.4
Updated: 2021/12/16

ChemScene

Product number: CS-1383
Product name: mTORinhibitor-3
Purity: 98.54%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

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MTOR inhibitor Chemical Properties,Usage,Production

Uses

mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

in vivo

mTOR inhibitor-3 (Compound 8h) has high free plasma clearance in both mice (1818 mL/min/kg) and rats (1538 mL/min/kg in rat) ^[1]. mTOR inhibitor-3 (Compounds 12i) is selected for this study due to its potency, selectivity, and favorable mouse PK profile. Plasma levels of mTOR inhibitor-3 6 h following oral administration in PC3 tumor-bearing mice along with the fold decreases of phosphorylated mTORC1 and -2 substrates relative to time-matched vehicle controls. mTOR inhibitor-3 has moderate terminal elimination half-life (t_1/2=1.7 h for mouse(1 mg/kg, iv)). mTOR inhibitor-3 achieves tumor stasis at the highest 200 mg/kg/day dose examined, which appears to also be approaching the limit of tolerability for this molecule^[2].

IC 50

mTOR: 1.5 nM (Ki); mTORC1; mTORC2

References

[1] Pei Z, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. DOI:10.1021/ml3003132
[2] Koehler MF, et al. Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity. J Med Chem. 2012 Dec 27;55(24):10958-71. DOI:10.1021/jm301389h

MTOR inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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MTOR inhibitor Suppliers

China 34 United States 7 Global 41

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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MedChemexpress LLC

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Sichuan Wei Keqi Biological Technology Co., Ltd.

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LETOPHARM LIMITED

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SPIRO PHARMA

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Amadis Chemical Company Limited

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Musechem

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Shenzhen Regent Biochemical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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1207358-59-5, MTOR inhibitorRelated Search:

mTOR inhibitor (mTOR-IN-1)

MTOR inhibitor

MTOR-IN-1

N-Ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea

GDC-mTOR inhibitor

mTOR inhibitor-3

Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]-

Inhibitor,inhibit,mTOR,mTOR inhibitor 3,mTOR inhibitor-3,mTOR inhibitor3,Mammalian target of Rapamycin

mTOR inhibitor-3, 10 mM in DMSO

1207358-59-5

C25H30N8O2