ChemicalBook > CAS DataBase List > AZD 2932

AZD 2932

Product Name: AZD 2932
CAS No.: 883986-34-3
Chemical Name: AZD 2932
Synonyms: CS-1792;AZD 2932;AGN-PC-00AQ5T;AZD2932 ，S7003;AZD 2932 USP/EP/BP;AZD2932, 10 mM in DMSO;AZD 2932; AZD-2932; AGN-PC-00AQ5T;AZD2932;2-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide;Benzeneacetamide, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-;2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide AZD2932
CBNumber: CB52667071
Molecular Formula: C24H25N5O4
Formula Weight: 447.49
MOL File: 883986-34-3.mol

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AZD 2932 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17741
Product name: AZD 2932
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17741
Product name: AZD 2932
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 17741
Product name: AZD 2932
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 17741
Product name: AZD 2932
Purity: ≥98%
Packaging: 25mg
Price: $230
Updated: 2024/03/01

TRC

Product number: A808170
Product name: AZD2932
Packaging: 25mg
Price: $125
Updated: 2021/12/16

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AZD 2932 Chemical Properties,Usage,Production

Uses

AZD2932 is a potent and multi-targeted protein tyrosine kinase inhibitor of VEFGR-2 and PDGFR.

Biological Activity

azd2932 is a potent inhibitor for multiple protein tyrosine kinases (ic50 = 8 nm, 4 nm, 7 nm, and 9 nm for vegfr-2, pdgfrβ, flt-3, and c-kit, respectively.) [1]vegfr are receptors for vascular endothelial growth factor and belong to receptor tyrosine kinases. it mediates in various cellular functions, including endothelial proliferation, migration, survival, tubular morphogenesis and sprouting. pdgfr are platelet-derived growth factor receptors that exhibit intracellular tyrosine kinase activity. it involves in embryonic development, angiogenesis, proliferation and differentiation etc.azd2932 has a potent and balanced profile against pdgfr, vegfr-2, flt-3 and c-kit (ic50: 0.009). it also has a good fraction unbound between 3.3% free in human and 7.0% in dog sera and has no activity against herg. [1]in female nude mice bearing c6 tumors, azd2932 treatment at 3–50 mg/kg b.i.d. 10 h apart give 60–80% inhibition of both p-vegfr-2 and p-pdgfrb in a 1:1 ratio. [1]

References

1. plé pa, jung f, ashton s, hennequin l et al. discovery of azd2932, a new quinazoline ether inhibitor with high affinity for vegfr-2 and pdgfr tyrosine kinases. bioorg med chem lett. 2012 jan 1;22(1):262-6.

AZD 2932 Preparation Products And Raw materials

Raw materials

Preparation Products

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883986-34-3, AZD 2932Related Search:

AZD 2932

2-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide

2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide AZD2932

Benzeneacetamide, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-

CS-1792

AGN-PC-00AQ5T

AZD 2932; AZD-2932; AGN-PC-00AQ5T;AZD2932

AZD 2932 USP/EP/BP

Platelet-derived growth factor receptor,Inhibitor,VEGFR,c-Kit,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,Vascular endothelial growth factor receptor,FLT3,SCFR,AZD-2932,AZD2932,inhibit,PDGFR,AZD 2932,CD117,CD135

AZD2932, 10 mM in DMSO

AZD2932 ，S7003

883986-34-3

C24H25N5O4

Inhibitors