Leukadherin 1 Property

Boiling point:

634.7±65.0 °C(Predicted)

Density 

1.50±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: soluble3mg/mL, clear (warmed)

pka

4.11±0.10(Predicted)

form 

powder

color 

, yellow to orange to brown

Safety

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

Leukadherin 1 Chemical Properties,Usage,Production

Uses

Leukadherin 1 is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1 (1). Complement receptor 3 (CR3, CD11b/CD18) is a cell surface receptor expressed on myeloid and natural killer cells (2).

Biological Activity

leukadherin 1 is an activator of cd11b/cd18 [1].cd11b/cd18 is a cell surface adhesion receptor that mediates immune functions and leukocyte migration and is expressed primarily in the cells of the innate immune system.leukadherin 1 is a cd11b/cd18 activator. leukadherin 1 increased cd11b/cd18-dependent cell adhesion to fibrinogen with ec50 value of 4 μm [1]. leukadherin 1 increased cd11b/cd18-dependent cell adhesion to its ligand icam-1. in k562 cells, leukadherin 1 increased the binding of cd11b/cd18 to icam-1 through the formation of long membrane tethers [2].in the acute peritonitis mice model, leukadherin 1 significantly reduced neutrophil accumulation by 40% [1]. in a mhc mismatched orthotopic kidney transplantation mouse model, leukadherin 1 reduced interstitial leukocyte infiltration, glomerular damage, neointimal hyperplasia and prolonged survival from 48.5% (csa only) to 100% (csa and la1) [3]. in newborn rats exposed to hyperoxia (85% o2), leukadherin 1 reduced both macrophage and neutrophil infiltration in the lungs [4].

References

[1]. maiguel d, faridi mh, wei c, et al. small molecule-mediated activation of the integrin cd11b/cd18 reduces inflammatory disease. sci signal, 2011, 4(189): ra57.
[2]. celik e1, faridi mh, kumar v, et al. agonist leukadherin-1 increases cd11b/cd18-dependent adhesion via membrane tethers. biophys j, 2013, 105(11): 2517-2527.
[3]. khan sq, guo l, cimbaluk dj, et al. a small molecule b2 integrin agonist improves chronic kidney allograft survival by reducing leukocyte recruitment and accompanying vasculopathy. front med (lausanne), 2014, 1: 45.
[4]. jagarapu j, kelchtermans j, rong m, et al. leukadherin-1 attenuates hyperoxia-induced lung injury in neonatal rats. am j respir cell mol biol, 2015.