α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)-
- Product Name
- α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)-
- CAS No.
- 1103738-17-5
- Chemical Name
- α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)-
- Synonyms
- SOTA-003;EOS-61340;α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)-;α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)-;(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[3,2-d][1,3]dioxole-5-carboxylic acid;(3aS,5R,6S,6aS)-6-Hydroxy-2,2-dimethyl-tetrahydro-2H-furo[2,3-d][1,3]dioxole-5-carboxylic acid
- CBNumber
- CB52668371
- Molecular Formula
- C8H12O6
- Formula Weight
- 204.18
- MOL File
- 1103738-17-5.mol
α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)- Property
- Boiling point:
- 399.5±42.0 °C(Predicted)
- Density
- 1.420±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.96±0.60(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6310DN
- Product name
- (3As,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-tetrahydro-2H-furo[2,3-d][1,3]dioxole-5-carboxylicacid
- Packaging
- 100mg
- Price
- $154
- Updated
- 2021/12/16
- Product number
- 6310DN
- Product name
- (3As,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-tetrahydro-2H-furo[2,3-d][1,3]dioxole-5-carboxylicacid
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 6310DN
- Product name
- (3As,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-tetrahydro-2H-furo[2,3-d][1,3]dioxole-5-carboxylicacid
- Packaging
- 1g
- Price
- $397
- Updated
- 2021/12/16
- Product number
- CD70002652
- Product name
- (3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $589
- Updated
- 2021/12/16
- Product number
- CM104460
- Product name
- (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyl-tetrahydro-2H-furo[2,3-d][1,3]dioxole-5-carboxylicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $594
- Updated
- 2021/12/16
α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)- Chemical Properties,Usage,Production
Synthesis
114861-22-2
1103738-17-5
(3aS,5S,6R,6aS)-5-(Hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol (25.0 g, 131 mmol) was used as a raw material and dissolved in a solvent mixture of acetone (375 mL) and H2O (125 mL). NaHCO3 (33.0 g, 3.0 equiv), NaBr (2.8 g, 20 mol%) and TEMPO (0.40 g, 2 mol%) were added sequentially. The reaction mixture was cooled to 0-5 °C and subsequently trichloroisocyanuric acid (TCCA, 30.5 g, 1.0 eq.) was added in batches. The reaction mixture was stirred continuously at 20 °C for 24 hours. Upon completion of the reaction, methanol (20 mL) was added and stirring was continued at 20 °C for 1 h. At this time, the formation of a white suspension was observed. The solids were separated by filtration and the filter cake was washed with acetone (50 mL). The filtrate was concentrated under reduced pressure to remove the organic solvent and the aqueous layer was extracted three times with EtOAc (300 mL). The organic layers were combined and concentrated to give an oily mixture containing a small solid residue. Acetone (125 mL) was added to the mixture and the acetone solution was concentrated by filtration to give the final target product (3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid as a yellow solid (21.0 g, 79% yield). The product was confirmed by 1H NMR (methanol-d4), δ 6.00 (d, J = 3.2 Hz, 1H), 4.72 (d, J = 3.2 Hz, 1H), 4.53 (d, J = 3.2 Hz, 1H), 4.38 (d, J = 3.2 Hz, 1H), 1.44 (s, 3H), 1.32 (s, 3H).
References
[1] Patent: US2009/30198, 2009, A1. Location in patent: Page/Page column 7-8
[2] Patent: US2010/16422, 2010, A1. Location in patent: Page/Page column 4
[3] Patent: EP2332947, 2011, A1. Location in patent: Page/Page column 6-7
[4] Patent: EP2661256, 2018, B1. Location in patent: Paragraph 0090
[5] Patent: CN106892948, 2017, A. Location in patent: Paragraph 0192; 0193; 0194
α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)- manufacturers
- Product
- α-L-Xylofuranuronic acid, 1,2-O-(1-Methylethylidene)- 1103738-17-5
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 95%-98%
- Supply Ability
- 100
- Release date
- 2019-09-04