ChemicalBook > CAS DataBase List > 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-

Product Name
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-
CAS No.
911715-90-7
Chemical Name
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-
Synonyms
AZD 8797;KAND-567;Rugocrixan;KAN-0440567;AZD8797( KAND567);AZD 8797; AZD-8797;CX3CR1 antagonist 18a;AZD8797, 10 mM in DMSO;Rugocrixan (Synonyms: AZD8797;(R)-2-(2-AMINO-5-((S)-1-PHENYLETHYLTHIO)THIAZOLO[4,5-D]PYRIMIDIN-7-YLAMINO)-4- METHYLPENTAN-1-OL
CBNumber
CB52668548
Molecular Formula
C19H25N5OS2
Formula Weight
403.56
MOL File
911715-90-7.mol
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1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Property

Boiling point:
651.1±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 150 mg/mL (371.69 mM)
form 
Solid
pka
14.47±0.10(Predicted)
color 
Light yellow to yellow
InChIKey
ZMQSLMZOWVGBSM-GXTWGEPZSA-N
SMILES
C(O)[C@H](NC1N=C(S[C@H](C2=CC=CC=C2)C)N=C2N=C(N)SC2=1)CC(C)C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P313Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A632400
Product name
(2R)-2-[[2-Amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol
Packaging
1mg
Price
$395
Updated
2021/12/16
ChemScene
Product number
CS-6469
Product name
AZD8797
Purity
98.65%
Packaging
10mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-6469
Product name
AZD8797
Purity
98.65%
Packaging
25mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-6469
Product name
AZD8797
Purity
98.65%
Packaging
50mg
Price
$1500
Updated
2021/12/16
ChemScene
Product number
CS-6469
Product name
AZD8797
Purity
98.65%
Packaging
100mg
Price
$2100
Updated
2021/12/16
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1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Chemical Properties,Usage,Production

Uses

(2R)-2-[[2-Amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol is an allosteric non-competitive modulator of the human CX3CR1 receptor. It can be used to develop treatment for multiple sclerosis.

in vivo

AZD8797 treatment in Dark Agouti rats with myelin oligodendrocyte glycoprotein-induced EAE results in reduced paralysis, CNS pathology, and incidence of relapses. The compound is effective when starting treatment before onset, as well as after the acute phase[2].

IC 50

CX3CR1: 3.9 nM (Ki, 125I-CX3CL-CX3CR1 in HEK293S cells); 125I-IL-8-CXCR2: 2800 nM (Ki, in HEK293S cells)

1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- Suppliers

China 43 United States 5 USA 1 Global 49
Xingji Pharmaceutical (Shanghai) Co., Ltd
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support@utgene.com
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MedChemexpress LLC
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021-58955995
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Shanghai Synmedia Chemical Co., Ltd.
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Shanghai Lollane Biological Technology Co.,Ltd.
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Shanghai EFE Biological Technology Co., Ltd.
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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911715-90-7, 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-Related Search:


  • 1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)-
  • AZD 8797; AZD-8797
  • CX3CR1 antagonist 18a
  • AZD 8797
  • (R)-2-(2-AMINO-5-((S)-1-PHENYLETHYLTHIO)THIAZOLO[4,5-D]PYRIMIDIN-7-YLAMINO)-4- METHYLPENTAN-1-OL
  • (2R)-2-[(2-amino-5-{[(1S)-1-phenylethyl]sulfanyl}-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol
  • AZD8797( KAND567)
  • (R)-2-((2-Amino-5-(((S)-1-phenylethyl)thio)thiazolo[4,5-d]pyrimidin-7-yl)amino)-4-methylpentan-1-ol , AZD8797
  • AZD8797, 10 mM in DMSO
  • KAND-567
  • KAN-0440567
  • Rugocrixan (Synonyms: AZD8797
  • Rugocrixan
  • 911715-90-7