Donepezil-d4 Hydrochloride
- Product Name
- Donepezil-d4 Hydrochloride
- CAS No.
- 1219798-88-5
- Chemical Name
- Donepezil-d4 Hydrochloride
- Synonyms
- Isoflurane Impurity 11;Donepezil-d4 Hydrochloride;2,3-dihydro-5,6-dimethoxy-2[[1-(phenylmethyl-d2)-4-piperidinyl]methyl-d2]-1H-inden-1-one,monohydrochloride
- CBNumber
- CB52670075
- Molecular Formula
- C24H30ClNO3
- Formula Weight
- 415.96
- MOL File
- 1219798-88-5.mol
Donepezil-d4 Hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 0.5 mg/ml
- form
- A crystalline solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 18251
- Product name
- Donepezil-d4 (hydrochloride)
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 500μg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 18251
- Product name
- Donepezil-d4 (hydrochloride)
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 1mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 18251
- Product name
- Donepezil-d4 (hydrochloride)
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 5mg
- Price
- $721
- Updated
- 2024/03/01
- Product number
- D17086
- Product name
- (+/-)-Donepezil-d4HCl(bis-methylene-d4)
- Packaging
- 25mg
- Price
- $890
- Updated
- 2021/12/16
- Product number
- 2668EL
- Product name
- 2-[Dideuterio-[1-[dideuterio(phenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
- Packaging
- 1mg
- Price
- $293
- Updated
- 2021/12/16
Donepezil-d4 Hydrochloride Chemical Properties,Usage,Production
Biological Activity
Donepezil-d4 (hydrochloride) is intended for use as an internal standard for the quantification of donepezil by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50 = 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.1 As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.2,3
References
1.Mu?oz-Torrero, D.Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's diseaseCurr. Med. Chem.152433-2455(2008) 2.Ramalingayya, G.V., Nampoothiri, M., Nayak, P.G., et al.Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasksPharmacogn. Mag.12(Suppl 1)S63-S70(2016) 3.Shumizu, S., Mizuguchi, Y., Sobue, A., et al.Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in miceJ. Pharmacol. Sci.127(4)439-445(2015)
Donepezil-d4 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Donepezil-d4 Hydrochloride Suppliers
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