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CP-547632 (hydrochloride)

Product Name
CP-547632 (hydrochloride)
CAS No.
252003-71-7
Chemical Name
CP-547632 (hydrochloride)
Synonyms
CP-547632 HYDROCHLORIDE;CP-547632 hydrochloride【PZ0264】;CP-547632 hydrochloride (PAN-90806);CP-547632 hydrochloride >=98% (HPLC);CP 547632 hydrochloride,CP547632 hydrochloride
CBNumber
CB52671229
Molecular Formula
C20H25BrClF2N5O3S
Formula Weight
568.86
MOL File
252003-71-7.mol
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CP-547632 (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMSO: 38.33 mg/mL (67.38 mM); Water: < 0.1 mg/mL (insoluble)
form 
Solid
color 
White to light yellow
InChIKey
NNPJZJJMQDXYGN-UHFFFAOYSA-N
SMILES
NC(C1=C(NC(NCCCCN2CCCC2)=O)SN=C1OCC3=C(F)C=C(Br)C=C3F)=O.[H]Cl
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0025143
Product name
CP-547632(hydrochloride)
Purity
98.24%
Packaging
5mg
Price
$95
Updated
2021/12/16
ChemScene
Product number
CS-0025143
Product name
CP-547632(hydrochloride)
Purity
98.24%
Packaging
10mg
Price
$170
Updated
2021/12/16
ChemScene
Product number
CS-0025143
Product name
CP-547632(hydrochloride)
Purity
98.24%
Packaging
25mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0025143
Product name
CP-547632(hydrochloride)
Purity
98.24%
Packaging
50mg
Price
$580
Updated
2021/12/16
ChemScene
Product number
CS-0025143
Product name
CP-547632(hydrochloride)
Purity
98.24%
Packaging
100mg
Price
$950
Updated
2021/12/16
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CP-547632 (hydrochloride) Chemical Properties,Usage,Production

Uses

CP-547632 hydrochloride is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 hydrochloride is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 hydrochloride has antitumor efficacy[1].

Biological Activity

CP-547632 hydrochloride is an orally active, ATP-competitive VEGFR-2 and FGF kinase inhibitor with IC50 of 11 nM and 9 nM, respectively. It is selective for VEGFR2 and bFGF over EGFR, PDGFRβ and related tyrosine kinases (TKs), and has an antitumor effects.

in vitro

CP-547632 hydrochloride (1-1000 nM; 1 hour) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC 50 value of 6 nM.

Western Blot Analysis

Cell Line: Serum-deprived cells
Concentration: 1, 4, 16, 63, 250, 1000 nM
Incubation Time: 1 hours
Result: Inhibited VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion.

in vivo

CP-547632 hydrochloride (po; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB- 231 xenografts.
CP-547632 hydrochloride (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours.

Animal Model: Mice bearing tumors (75-150 mm in size)
Dosage: 6.25, 12.5, 25, 50, 100 mg/kg
Administration: Po; daily; 10-24 days
Result: Caused a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
< td class="col2"> H-ras tumor-bearing mice
Animal Model:
Dosage: 50 mg /kg
Administration: Oral
Result: A single oral dose of 50 mg/kg yielded plasma concentrations above 500 ng/ml for 12 hours.

target

VEGFR-2

< span> 11 nM (IC 50 )

FGFR

9 nM (IC 50 )

IC 50

VEGFR-2: 11 nM (IC50); FGFR: 9 nM (IC50)

References

[1] Beebe JS, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003 Nov 1;63(21):7301-9. PMID:14612527

CP-547632 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-547632 (hydrochloride) Suppliers

CHINA 26 United States 5 Global 31
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9550
Advantage
58
TOSUN PHARM
Tel
61855200 13326451905
Email
3003386889@qq.com
Country
China
ProdList
7958
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10343
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58

252003-71-7, CP-547632 (hydrochloride)Related Search:


  • CP-547632 HYDROCHLORIDE
  • CP-547632 hydrochloride >=98% (HPLC)
  • CP-547632 hydrochloride (PAN-90806)
  • CP 547632 hydrochloride,CP547632 hydrochloride
  • CP-547632 hydrochloride【PZ0264】
  • 252003-71-7