2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

Product Name: 2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
CAS No.: 1008119-07-0
Chemical Name: 2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
Synonyms: 3,5-Difluoro-4-carboxyphenylboronic acid, pinacol ester;2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid;Benzoic acid, 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB52672837
Molecular Formula: C13H15BF2O4
Formula Weight: 284.06
MOL File: 1008119-07-0.mol

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2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid Property

Boiling point:: 370.3±42.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.23±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D451978
Product name: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: Y3511
Product name: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzoicacid
Packaging: 250mg
Price: $123
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0006273
Product name: 2,6-DIFLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $499
Updated: 2021/12/16

Matrix Scientific

Product number: 096443
Product name: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0006273
Product name: 2,6-DIFLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1315.65
Updated: 2021/12/16

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2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid Chemical Properties,Usage,Production

Synthesis

183065-68-1

73183-34-3

1008119-07-0

Under argon protection, 2,6-difluoro-4-bromobenzoic acid (0.4 g, 1.6 mmol), pinacol ester of bisboronic acid (0.5 g, 2.0 mmol), PdCl2(dppf) (0.12 g, 0.17 mmol), and potassium acetate (0.49 g, 4.9 mmol) were dissolved in dioxane (16.5 mL). The reaction mixture was transferred to a sealed vial and degassed twice by vacuum-N2 displacement cycle. Subsequently, the reaction system was heated to 80 °C and the reaction was stirred at this temperature for 21 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a short column of silica gel to remove solid impurities. The filtrate was concentrated under reduced pressure and purified by fast column chromatography (ISCO 12 g silica gel column with an elution gradient of 20-100% ethyl acetate/hexane) to afford the target product, 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, as a brown oil (0.11 g, 19% yield). Mass Spectrometry (ES-) m/z: 283 ([M-H]-); Liquid Chromatography Retention Time: 1.48 min (Analytical HPLC Method D).

References

[1] Patent: US2009/75995, 2009, A1. Location in patent: Page/Page column 67

2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid Suppliers

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1008119-07-0, 2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acidRelated Search:

2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

3,5-Difluoro-4-carboxyphenylboronic acid, pinacol ester

Benzoic acid, 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

1008119-07-0

C13H15BF2O4