ChemicalBook > CAS DataBase List > 2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

Product Name
2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
CAS No.
1008119-07-0
Chemical Name
2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
Synonyms
3,5-Difluoro-4-carboxyphenylboronic acid, pinacol ester;2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid;Benzoic acid, 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber
CB52672837
Molecular Formula
C13H15BF2O4
Formula Weight
284.06
MOL File
1008119-07-0.mol
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2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid Property

Boiling point:
370.3±42.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
2.23±0.10(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D451978
Product name
2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
Y3511
Product name
2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzoicacid
Packaging
250mg
Price
$123
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BOR0006273
Product name
2,6-DIFLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID
Purity
95.00%
Packaging
5MG
Price
$499
Updated
2021/12/16
Matrix Scientific
Product number
096443
Product name
2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BOR0006273
Product name
2,6-DIFLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID
Purity
95.00%
Packaging
1G
Price
$1315.65
Updated
2021/12/16
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2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid Chemical Properties,Usage,Production

Synthesis

183065-68-1

73183-34-3

1008119-07-0

Under argon protection, 2,6-difluoro-4-bromobenzoic acid (0.4 g, 1.6 mmol), pinacol ester of bisboronic acid (0.5 g, 2.0 mmol), PdCl2(dppf) (0.12 g, 0.17 mmol), and potassium acetate (0.49 g, 4.9 mmol) were dissolved in dioxane (16.5 mL). The reaction mixture was transferred to a sealed vial and degassed twice by vacuum-N2 displacement cycle. Subsequently, the reaction system was heated to 80 °C and the reaction was stirred at this temperature for 21 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a short column of silica gel to remove solid impurities. The filtrate was concentrated under reduced pressure and purified by fast column chromatography (ISCO 12 g silica gel column with an elution gradient of 20-100% ethyl acetate/hexane) to afford the target product, 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, as a brown oil (0.11 g, 19% yield). Mass Spectrometry (ES-) m/z: 283 ([M-H]-); Liquid Chromatography Retention Time: 1.48 min (Analytical HPLC Method D).

References

[1] Patent: US2009/75995, 2009, A1. Location in patent: Page/Page column 67

2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid Suppliers

China 22 India 1 United States 6 Global 29
Alfa Chemistry
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1008119-07-0, 2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acidRelated Search:


  • 2,6-Difluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
  • 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
  • 3,5-Difluoro-4-carboxyphenylboronic acid, pinacol ester
  • Benzoic acid, 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 1008119-07-0
  • C13H15BF2O4