3-(4-fluorophenylaMino)-3-oxopropanoic acid
- Product Name
- 3-(4-fluorophenylaMino)-3-oxopropanoic acid
- CAS No.
- 95262-10-5
- Chemical Name
- 3-(4-fluorophenylaMino)-3-oxopropanoic acid
- Synonyms
- Cabozantinib Impurity 68;3-(4-fluorophenylaMino)-3-oxopropanoic acid;Propanoic acid, 3-[(4-fluorophenyl)amino]-3-oxo-
- CBNumber
- CB52676471
- Molecular Formula
- C9H8FNO3
- Formula Weight
- 197.16
- MOL File
- 95262-10-5.mol
3-(4-fluorophenylaMino)-3-oxopropanoic acid Property
- Melting point:
- 142 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 450.6±30.0 °C(Predicted)
- Density
- 1.430±0.06 g/cm3(Predicted)
- pka
- -0.37±0.32(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2232AL
- Product name
- 3-(4-Fluoroanilino)-3-oxopropanoicacid
- Packaging
- 1g
- Price
- $569.6
- Updated
- 2021/12/16
- Product number
- CD12002278
- Product name
- 3-((4-Fluorophenyl)amino)-3-oxopropanoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $1004
- Updated
- 2021/12/16
- Product number
- 95262105
- Product name
- 3-(4-Fluorophenylamino)-3-oxopropanoicacid
- Packaging
- 250mg
- Price
- $156.96
- Updated
- 2021/12/16
- Product number
- CD12002278
- Product name
- 3-((4-Fluorophenyl)amino)-3-oxopropanoicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $339
- Updated
- 2021/12/16
- Product number
- 95262105
- Product name
- 3-(4-Fluorophenylamino)-3-oxopropanoicacid
- Packaging
- 1g
- Price
- $364.61
- Updated
- 2021/12/16
3-(4-fluorophenylaMino)-3-oxopropanoic acid Chemical Properties,Usage,Production
Synthesis
Step 1: Synthesis of ethyl 3-(4-fluorophenylamino)-3-oxopropionate.
Organic solution of diethyl malonate was added to organic solution of 4-fluorophenylamine and heated to reflux until the reaction was complete. The reaction solution was cooled to room temperature, n-hexane was added to the reaction solution, filtered, the filter residue was washed with water, and the residue was recrystallized to give ethyl 3-(4-fluorophenylamino)-3-oxopropanoate.
Step 2: Synthesis of 3-(4-fluorophenylamino)-3-oxopropanoic acid.
An aqueous solution of base was added to an organic solution of ethyl 3-(4-fluorophenylamino)-3-oxopropanoate and stirred until the reaction was complete. The organic solvent in the reaction solution was spun dry and extracted, then the pH of the aqueous phase was adjusted to 7 with hydrochloric acid solution, extracted, and the organic layers were combined and dried and spun dry to produce 3-(4-fluorophenylamino)-3-oxopropanoic acid.
3-(4-fluorophenylaMino)-3-oxopropanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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