[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
- Product Name
- [4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
- CAS No.
- 204319-69-7
- Chemical Name
- [4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
- Synonyms
- 2-Thiazolemethanol, 4-(trifluoromethyl)-;(4-(Trifluoromethyl)thiazol-2-yl)methanol;[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
- CBNumber
- CB52676835
- Molecular Formula
- C5H4F3NOS
- Formula Weight
- 183.15
- MOL File
- 204319-69-7.mol
[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol Property
- Boiling point:
- 205.1±40.0 °C(Predicted)
- Density
- 1.533±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.80±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T899233
- Product name
- [4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- P000236056
- Product name
- (4-(Trifluoromethyl)thiazol-2-yl)methanol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $206
- Updated
- 2021/12/16
- Product number
- P000236056
- Product name
- (4-(Trifluoromethyl)thiazol-2-yl)methanol
- Purity
- 97%
- Packaging
- 100mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- HCH0356186
- Product name
- (4-(TRIFLUOROMETHYL)THIAZOL-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.76
- Updated
- 2021/12/16
- Product number
- P000236056
- Product name
- (4-(Trifluoromethyl)thiazol-2-yl)methanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $514
- Updated
- 2021/12/16
[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol Chemical Properties,Usage,Production
Synthesis
79247-86-2
204319-69-7
Sodium tetrahydroborate (840 mg) was slowly added to a methanolic solution (15 mL) of ethyl 4-trifluoromethylthiazole-2-carboxylate (2.5 g) at 0 °C, the reaction system was kept at 0 °C and stirred continuously for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting residue was diluted with distilled water and subsequently extracted with ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated again under reduced pressure to remove the solvent. The final product was purified by silica gel column chromatography (NH silica gel, eluent hexane/ethyl acetate mixed solvent) to afford (4-(trifluoromethyl)thiazol-2-yl)methanol (1.7 g) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 4.78 (2H, d, J = 5.5 Hz), 6.28 (1H, t, J = 5.6 Hz), 8.41 (1H, s).
References
[1] Patent: WO2015/5489, 2015, A1. Location in patent: Paragraph 0298
[2] Patent: WO2018/188795, 2018, A1. Location in patent: Page/Page column 51-52
[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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