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[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol

Product Name
[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
CAS No.
204319-69-7
Chemical Name
[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
Synonyms
2-Thiazolemethanol, 4-(trifluoromethyl)-;(4-(Trifluoromethyl)thiazol-2-yl)methanol;[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
CBNumber
CB52676835
Molecular Formula
C5H4F3NOS
Formula Weight
183.15
MOL File
204319-69-7.mol
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[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol Property

Boiling point:
205.1±40.0 °C(Predicted)
Density 
1.533±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.80±0.10(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T899233
Product name
[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
Packaging
10mg
Price
$45
Updated
2021/12/16
Ark Pharm
Product number
P000236056
Product name
(4-(Trifluoromethyl)thiazol-2-yl)methanol
Purity
97%
Packaging
250mg
Price
$206
Updated
2021/12/16
Ark Pharm
Product number
P000236056
Product name
(4-(Trifluoromethyl)thiazol-2-yl)methanol
Purity
97%
Packaging
100mg
Price
$118
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0356186
Product name
(4-(TRIFLUOROMETHYL)THIAZOL-2-YL)METHANOL
Purity
95.00%
Packaging
5MG
Price
$503.76
Updated
2021/12/16
Ark Pharm
Product number
P000236056
Product name
(4-(Trifluoromethyl)thiazol-2-yl)methanol
Purity
97%
Packaging
1g
Price
$514
Updated
2021/12/16
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[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol Chemical Properties,Usage,Production

Synthesis

79247-86-2

204319-69-7

Sodium tetrahydroborate (840 mg) was slowly added to a methanolic solution (15 mL) of ethyl 4-trifluoromethylthiazole-2-carboxylate (2.5 g) at 0 °C, the reaction system was kept at 0 °C and stirred continuously for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting residue was diluted with distilled water and subsequently extracted with ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated again under reduced pressure to remove the solvent. The final product was purified by silica gel column chromatography (NH silica gel, eluent hexane/ethyl acetate mixed solvent) to afford (4-(trifluoromethyl)thiazol-2-yl)methanol (1.7 g) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 4.78 (2H, d, J = 5.5 Hz), 6.28 (1H, t, J = 5.6 Hz), 8.41 (1H, s).

References

[1] Patent: WO2015/5489, 2015, A1. Location in patent: Paragraph 0298
[2] Patent: WO2018/188795, 2018, A1. Location in patent: Page/Page column 51-52

[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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[4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol Suppliers

China 28 India 2 United States 2 Global 32
Synthonix Inc
Tel
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Fax
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Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
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Fax
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Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69

204319-69-7, [4-(trifluoromethyl)-1,3-thiazol-2-yl]methanolRelated Search:

4-TRIFLUOROMETHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER 2-Thiazolecarboxaldehyde, 4-trifluoroMethyl-

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