ChemicalBook > CAS DataBase List > Arginase inhibitor 1

Arginase inhibitor 1

Product Name: Arginase inhibitor 1
CAS No.: 1345808-25-4
Chemical Name: Arginase inhibitor 1
Synonyms: Arginase inhibitor 1;1-Piperidinebutanoic acid, α-amino-α-(4-boronobutyl)-, (αR)-;(alphaR)-alpha-Amino-alpha-(4-boronobutyl)-1-piperidinebutanoic acid
CBNumber: CB52677054
Molecular Formula: C13H27BN2O4
Formula Weight: 286.18
MOL File: 1345808-25-4.mol

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Arginase inhibitor 1 Property

Boiling point:: 523.0±60.0 °C(Predicted)
Density: 1.147±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: 50 mg/ml; Water: 30 mg/ml
form: Powder
pka: 2.22±0.44(Predicted)
color: White to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28418
Product name: Arginase Inhibitor 1
Packaging: 1mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 28418
Product name: Arginase Inhibitor 1
Packaging: 5mg
Price: $684
Updated: 2024/03/01

AK Scientific

Product number: 1379DT
Product name: Arginaseinhibitor1
Packaging: 5mg
Price: $860
Updated: 2021/12/16

ChemScene

Product number: CS-1736
Product name: Arginaseinhibitor1
Purity: 98.00%
Packaging: 10mg
Price: $504
Updated: 2021/12/16

ApexBio Technology

Product number: B1009
Product name: Arginaseinhibitor1
Packaging: 10mg
Price: $662
Updated: 2021/12/16

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Arginase inhibitor 1 Chemical Properties,Usage,Production

Description

Arginase inhibitor 1 is an inhibitor of arginase I and II (IC₅₀s = 223 and 509 nM, respectively, for the recombinant human enzymes). It decreases arginase I activity in CHOK cells expressing human arginase I (IC₅₀ = 8 μM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion.

Uses

Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.

in vivo

Following i.v. dosing with 10 mg/kg in fasted animals, Arginase inhibitor 1has a terminal elimination half-life (t_1/2) of 3.3 h with a volume of distribution and total body clearance of 1.86 L/kg and 7.89 mL/min/kg, respectively. The oral bioavailability of Arginase inhibitor 1 (10 mg/kg, p.o.) is 28% with a C_max of 0.45 mg/L^[1].

References

[1] Van Zandt MC, et al. Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potentinhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013 Mar 28;56(6):2568-80. DOI:10.1021/jm400014c

Arginase inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1345808-25-4, Arginase inhibitor 1Related Search:

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Arginase inhibitor 1

(alphaR)-alpha-Amino-alpha-(4-boronobutyl)-1-piperidinebutanoic acid

1-Piperidinebutanoic acid, α-amino-α-(4-boronobutyl)-, (αR)-

1345808-25-4

C13H27BN2O4