LY3039478

ChemicalBook > CAS DataBase List > LY3039478

Product Name: LY3039478
CAS No.: 1421438-81-4
Chemical Name: LY3039478
Synonyms: LY3039478;Crenigacestat;LY3039478(Crenigacestat);CRENIGACESTAT (LY3039478);LY3039478; LY 3039478; LY-3039478; CRENIGACESTAT;4-trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6;Inhibitor,γ-secretase,Crenigacestat,liver,LY 3039478,Notch,Gamma secretase,inhibit,LY-3039478,CCRCC;4,4,4-Trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide;N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide;Butanamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluoro-
CBNumber: CB52677403
Molecular Formula: C22H23F3N4O4
Formula Weight: 464.44
MOL File: 1421438-81-4.mol

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LY3039478 Property

Boiling point:: 818.7±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥23.2 mg/mL in DMSO; insoluble in H2O; ≥89.4 mg/mL in EtOH with ultrasonic
form: solid
pka: 12.75±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27919
Product name: Crenigacestat
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 27919
Product name: Crenigacestat
Packaging: 10mg
Price: $384
Updated: 2024/03/01

Cayman Chemical

Product number: 27919
Product name: Crenigacestat
Packaging: 5mg
Price: $202
Updated: 2024/03/01

TRC

Product number: L468970
Product name: LY3039478
Packaging: 1mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-5807
Product name: Crenigacestat
Purity: 98.62%
Packaging: 5mg
Price: $168
Updated: 2021/12/16

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LY3039478 Chemical Properties,Usage,Production

Uses

LY 3039478 is used in the preparation of medicaments for combination antitumor therapy with Notch and PD-1 or PD-Li inhibitors.

Biological Activity

ly3039478 is a novel and potent notch inhibitor with ic50 of 0.41 nm.the novel and unique notch inhibitor, ly3039478, has progressed into clinical development by lilly co. ltd. ly3039478 displays the best overall profile and is unique within the sar investigated. ly3039478 displays interesting atropisomer phenomena. the average ly3039478 major/minor rotational isomer ratio ranged between 14 and 28 in plasma. the crystalline monohydrate form of ly3039478 consists of a single rotational isomer and is chemically and physically stable for at least 14 days under accelerated stability test conditions.

References

warren j. porter. discovery of a novel notch inhibitor. the 8th sci-rsc symposium on proteinase inhibitor design april 15-16, 2013, basel, switzerland.

LY3039478 Preparation Products And Raw materials

Raw materials

Preparation Products

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1421438-81-4, LY3039478Related Search:

4-trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6

LY3039478; LY 3039478; LY-3039478; CRENIGACESTAT

LY3039478

4,4,4-Trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide

N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide

Crenigacestat

Butanamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluoro-

CRENIGACESTAT (LY3039478)

LY3039478(Crenigacestat)

Inhibitor,γ-secretase,Crenigacestat,liver,LY 3039478,Notch,Gamma secretase,inhibit,LY-3039478,CCRCC

1421438-81-4

C22H23F3N4O4

APIS