(S)-b-AMino-4-Methoxy-benzeneethanol

Product Name: (S)-b-AMino-4-Methoxy-benzeneethanol
CAS No.: 191109-48-5
Chemical Name: (S)-b-AMino-4-Methoxy-benzeneethanol
Synonyms: (S)-p-hydroxyphenylglycinol;(S)-b-AMino-4-Methoxy-benzeneethanol;(S)-2-Amino-2-(4-methoxyphenyl)ethanol;(S)-2-Amino-2-(4-methoxyphenyl)ethan-1-ol;Benzeneethanol, β-amino-4-methoxy-, (βS)-;(2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL;(S)-2-amino-2-(4-methoxyphenyl)ethanol hydrochloride
CBNumber: CB52684223
Molecular Formula: C9H13NO2
Formula Weight: 167.21
MOL File: 191109-48-5.mol

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(S)-b-AMino-4-Methoxy-benzeneethanol Property

Boiling point:: 325.4±32.0 °C(Predicted)
Density: 1.128±0.06 g/cm3(Predicted)
pka: 12.54±0.10(Predicted)
InChI: InChI=1/C9H13NO2/c1-12-8-4-2-7(3-5-8)9(10)6-11/h2-5,9,11H,6,10H2,1H3/t9-/s3
InChIKey: OZNSMUSCZYUFHD-DJEYLCQNNA-N
SMILES: [C@@H](C1C=CC(OC)=CC=1)(N)CO |&1:0,r|

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Safety

HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CCH0030554
Product name: (2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL
Purity: 95.00%
Packaging: 5MG
Price: $505.77
Updated: 2021/12/16

ACHEMBLOCK

Product number: P40188
Product name: (S)-b-Amino-4-methoxy-benzeneethanol
Purity: 95%
Packaging: 250MG
Price: $200
Updated: 2021/12/16

Acrotein

Product number: B-0100
Product name: (S)-b-Amino-4-methoxy-benzeneethanol
Purity: 97%
Packaging: 0.5g
Price: $220
Updated: 2021/12/16

Alichem

Product number: 191109485
Product name: (S)-2-Amino-2-(4-methoxyphenyl)ethanol
Packaging: 1g
Price: $539
Updated: 2021/12/16

Crysdot

Product number: CD12101137
Product name: (S)-2-Amino-2-(4-methoxyphenyl)ethanol
Purity: 95+%
Packaging: 1g
Price: $607
Updated: 2021/12/16

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(S)-b-AMino-4-Methoxy-benzeneethanol Chemical Properties,Usage,Production

Physical properties

A white crystal

Uses

(S)-2-Amino-2-(4-methoxyphenyl)ethanol hydrochloride is used as an intermediate in laboratory research.

Reactions

(S)-b-AMino-4-Methoxy-benzeneethanol could synthize oxidatively cleavable chiral auxiliary-bearing tetramate derivative 1-[(S)-2-Hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-3-methyl-1H-pyrrol2(5H)-one with (E)-4-bromo-3-methoxy-2-methyl-2-butenoate. Due to its chirality, it can also be used to synthesize various chiral organics, such as 1-[(S) -2-hydroxy-1 -(4-methoxyphenyl)ethyl] -4-methoxy-3-methyl-1h-Pyrrol2 (5H)-one[1-2].

Synthesis

1.To an ice-cooled mixture of lithium borohydride (16.5 g, 759 mmol) in THF (270 mL) was added trimethylsilyl chloride (194 mL, 1.52 mol).
2.After stirring for 30 minutes, a mixture of (2S)-2-amino-2-(4-methoxyphenyl)acetic acid (45.9 g, 253 mmol) in THF (1.00 L) was added dropwise to the reaction.
3.Then the reaction mixture was stirred at rt overnight.
4.The reaction was quenched with MeOH, and the resulting mixture was concentrated in vacuo.The residue was diluted with 1M sodium hydroxide aq.solution and chloroform, and filtered through a pad of Celite.
5.The filtrate was diluted with brine, and organic layer was separated. The aqueous layer was extracted with chloroform. The combined organic extracts were dried over sodium sulfate, filtered, and concentrated in vacuo to give (S)-b-AMino-4-Methoxy-benzeneethanol (37.1 g) as red solids.

References

[1] Lan H, et al. The first enantioselective synthesis of cytotoxic marine natural product palau’imide and assignment of its C-20 stereochemistry. Chemical Communications, 2010; 46: 5319-532.
[2] Shemet A, et al. Total Synthesis of (?)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution. Organic Letters, 2017; 19: 5529–5532.

(S)-b-AMino-4-Methoxy-benzeneethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-b-AMino-4-Methoxy-benzeneethanol Suppliers

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