APY29

Product Name: APY29
CAS No.: 1216665-49-4
Chemical Name: APY29
Synonyms: APY29;CS-1412;APY 29; APY-29;Reaxys ID: 20097347;APY29, 10 mM in DMSO;N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;2,4-Pyrimidinediamine,N2-1H-benzimidazol-5-yl-N4-(3-cyclopropyl-1H-pyrazol-5-yl)-;2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-;N2-(1H-benzo[d]imidazol-6-yl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
CBNumber: CB52685321
Molecular Formula: C17H16N8
Formula Weight: 332.36
MOL File: 1216665-49-4.mol

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APY29 Property

Melting point:: >280°C (dec.)
Boiling point:: 782.3±70.0 °C(Predicted)
Density: 1.559±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.93±0.30(Predicted)
form: Solid
color: Pale Beige to Light Brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22913
Product name: APY-29
Purity: ≥98%
Packaging: 5mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 22913
Product name: APY-29
Purity: ≥98%
Packaging: 10mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 22913
Product name: APY-29
Purity: ≥98%
Packaging: 25mg
Price: $403
Updated: 2024/03/01

Cayman Chemical

Product number: 22913
Product name: APY-29
Purity: ≥98%
Packaging: 50mg
Price: $604
Updated: 2024/03/01

Tocris

Product number: 4865
Product name: APY29
Purity: ≥98%(HPLC)
Packaging: 50
Price: $934
Updated: 2021/12/16

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APY29 Chemical Properties,Usage,Production

Uses

APY29 is a modulator of inositol requiring enzyme IRE1α, a protein sited in the endoplasmic recticulum that has kinase and RNase activities triggered by endoplasmic recticulum stress. It also functions in the allosteric control of IRE1α endoribonuclease using kinase inhibitors for the development of drugs for endoplasmic recticulum stress related diseases.

Biological Activity

APY29 has the ability to enhance inositol requiring kinase enzyme 1 α (IRE1α) (P830L)μs oligomeric state to rescue RNase activity.', 'APY29 is a small molecule th at inhibits the kinase activity of IRE1α (in vitro autophosphorylation IC50 = 280 nM) by targeting its active site ATP-binding pocket, while simultaneously acting as an allosteric activator of IRE1α RNase activity (EC50 = 460 nM) by keeping the active site in an open conformation. When applied 1 hr prior to stress induction by 4-hr 6 nM thapsigargin treatment, APY29 significantly potentiates stress-induced unfolded protein response (UPR) in r at insulinoma INS-1 cultures (XBP1 mRNA processing induction = 54% without vs. 78% with 1-hr 3 μM APY29 pretreatment).

storage

Store at -20°C

APY29 Preparation Products And Raw materials

Raw materials

Preparation Products

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APY29 Suppliers

China 81 India 1 United Kingdom 1 United States 13 Global 96

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4589
Advantage: 55

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View Lastest Price from APY29 manufacturers

Career Henan Chemical Co

Product: APY29 1216665-49-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

1216665-49-4, APY29Related Search:

APY29

N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

N2-(1H-benzo[d]imidazol-6-yl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Reaxys ID: 20097347

CS-1412

APY 29; APY-29

2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-

2,4-Pyrimidinediamine,N2-1H-benzimidazol-5-yl-N4-(3-cyclopropyl-1H-pyrazol-5-yl)-

APY29, 10 mM in DMSO

1216665-49-4

C17H16N8