2-broMo-3-Methoxybenzaldehyde

2-broMo-3-Methoxybenzaldehyde Property

Melting point:

69.5-70 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))

Boiling point:

277.6±20.0 °C(Predicted)

Density 

1.522±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder

color 

Pale lemon

Safety

HS Code 

2912490090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

2-broMo-3-Methoxybenzaldehyde Chemical Properties,Usage,Production

Synthesis

To a mixed solution of N,N-dimethylformamide (60 mL) of 2-bromo-3-hydroxybenzaldehyde (1.30 g, 6.50 mmol) and potassium carbonate (2.70 g, 19.5 mmol) was added iodomethane (0.80 g, 12.9 mmol). The reaction mixture was stirred at room temperature for 16 h. After completion of the reaction, it was diluted with ethyl acetate (60 mL). The mixture was washed with saturated aqueous ammonium chloride solution (2 x 50 mL), the organic phase was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography using a 0 to 30% ethyl acetate/hexane gradient elution to afford 2-bromo-3-methoxybenzaldehyde as a yellow oil (1.50 g, quantitative yield). Mass spectrum (electrospray positive ion mode) m/z 215.1 ([M+H]+).

References

[1] Patent: US2018/162868, 2018, A1. Location in patent: Paragraph 1413-1414
[2] Journal of the American Chemical Society, 2017, vol. 139, # 9, p. 3360 - 3363
[3] Patent: US2016/75711, 2016, A1. Location in patent: Paragraph 0586-0587
[4] Journal of Organic Chemistry, 2018, vol. 83, # 10, p. 5791 - 5800