ChemicalBook > CAS DataBase List > Elobixibat

Elobixibat

Product Name: Elobixibat
CAS No.: 439087-18-0
Chemical Name: Elobixibat
Synonyms: A 3309;AZD-7806;AJG-533);Elosibat;Elobixibat;Elobixibat (G);Elobixibathydrate;Elobixibat In-House;Elobixibat (A-3309;Elobixibat (AZD-7806)
CBNumber: CB52694327
Molecular Formula: C36H45N3O7S2
Formula Weight: 695.89
MOL File: 439087-18-0.mol

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Elobixibat Property

Boiling point:: 969.6±65.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 3.20±0.10(Predicted)
color: White to off-white
InChIKey: XFLQIRAKKLNXRQ-UUWRZZSWSA-N
SMILES: C(O)(=O)CNC(=O)[C@@H](C1=CC=CC=C1)NC(COC1C=C2S(=O)(=O)CC(CCCC)(CCCC)CN(C3=CC=CC=C3)C2=CC=1SC)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E505200
Product name: Elobixibat
Packaging: 150mg
Price: $15490
Updated: 2021/12/16

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Elobixibat Chemical Properties,Usage,Production

Uses

Elobixibat, is an ileal sodium-dependent bile acid transporter ( IBAT) inhibitor, used for the treatment of chronic constipation and irritable bowel syndrome with constipation (IBS-C).

in vivo

Elobixibat (0.27 mg/kg/day for 20 weeks, p.o.) inhibits tumor growth in the mouse model of fatty liver disease by inhibiting bile acid reabsorption and reducing total and primary bile acid levels in serum and liver^[2].
Elobixibat (5 days a week for 4 weeks, 0.2, 0.6, or 1.2 mg/kg/day, gavage) improves NASH-related histopathology, reduces cytokine (TNF-α, IL-6, and TGF-β) expression, and normalizes gut microbiome composition in nonsteatohepatitis (NASH) mouse models^[3].

Animal Model:	Mouse Model of Nonalcoholic Steatohepatitis (three-week-old male C57BL/6J mice)^[2]
Dosage:	0.27 mg/kg/day for 20 weeks
Administration:	p.o.
Result:	Reduced the number and size of tumors. Significantly reduced the number of Gram-positive bacteria in the phyla Firmicutes, Deferobacteria and Actinobacteria and increased the number of Proteobacteria.

IC 50

IBAT: 0.53 nM (IC₅₀); IL-6; TNF-α; TNF-β

Elobixibat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Elobixibat manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: Elobixibat 439087-18-0
Price: US $12000.00/g
Min. Order: 1g
Purity: 99.0%min， single impurity：0.1%min
Supply Ability: 50kg
Release date: 2023-06-09

Senova Technology Co. Ltd.

Product: Elobixibat 439087-18-0
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 10KG
Release date: 2022-12-21

439087-18-0, ElobixibatRelated Search:

Elobixibat

L-Phencynonate Hydrochloride

Elobixibat (AZD-7806)

XFLQIRAKKLNXRQ-UUWRZZSWSA-N

AJG-533)

AZD-7806

Elobixibat (A-3309

A 3309

Glycine, (2R)-N-[2-[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,5-benzothiazepin-8-yl]oxy]acetyl]-2-phenylglycyl-

Elobixibathydrate

Elobixibat In-House

Elobixibat, >98% (HPLC)

Elosibat

Elobixibat (G)

(R)-2-(2-(2-((3,3-Dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-8-yl)oxy)acetamido)-2-phenylacetamido)acetic acid

439087-18-0

439087-16-0

C36H45N3O7S2

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals