ChemicalBook > CAS DataBase List > (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine

(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine

Product Name: (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine
CAS No.: 1371569-69-5
Chemical Name: (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine
Synonyms: BETP;BETP, 10 mM in DMSO;Glucagon-Like Peptide 1 Receptor Agonist II;Glucagon Receptor,BETP,inhibit,GCGR,Inhibitor;(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine;2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-pyrimidine;Pyrimidine, 2-(ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-
CBNumber: CB52694529
Molecular Formula: C20H17F3N2O2S
Formula Weight: 406.42
MOL File: 1371569-69-5.mol

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(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Property

Boiling point:: 569.5±60.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: -5.23±0.50(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0558
Product name: BETP
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $150
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0558
Product name: BETP
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $573
Updated: 2025/07/31

Sigma-Aldrich

Product number: 346007
Product name: Glucagon-Like Peptide 1 Receptor Agonist II
Packaging: 10 mg
Price: $231
Updated: 2025/07/31

Tocris

Product number: 4778
Product name: BETP
Purity: ≥98%(HPLC)
Packaging: 10
Price: $203
Updated: 2021/12/16

Tocris

Product number: 4778
Product name: BETP
Purity: ≥98%(HPLC)
Packaging: 50
Price: $836
Updated: 2021/12/16

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(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Chemical Properties,Usage,Production

Uses

(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoromethyl)pyrimidine acts as an allosteric modulator of the GLP-1 (glucagon-like peptide-1) receptor in preparation of orally therapeutic agents for the treatment of diabetes mellitus.

Biological Activity

BETP is a positive allosteric modulator of the GLP-1 receptor th at potentiates cAMP accumulation and glucose-dependent insulin release in pancreatic islet cells, in the presence of the weak GLP-1 metabolite, GLP-1(9-36). BETP has additive effects on the endogenous GLP-1 receptor ligand GLP-1(7-36).', 'BetP is a trimeric Na+-coupled betaine symporter. BetP belongs to the betaine-choline-carnitine transporter (BCCT) family. It controls transport activity in dependence of the cytoplasmic K+-concentration.

in vivo

BETP has insulinotropic effect in SD rats. BETP (10 mg/kg, jugular vein cannula) exhibits insulin secretagogue activity in the intravenous glucose tolerance test (IVGTT) model. BETP (10 mg/kg, i.v.)-treated rats need 20% higher glucose infusion rates and demonstrates higher plasma insulin levels in SD rat hyperglycemic clamp model^[1]. BETP (5 mg/kg) enhances oxyntomodulin-stimulated insulin secretion^[2].

storage

Store at +4°C

(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Suppliers

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View Lastest Price from (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine manufacturers

Career Henan Chemical Co

Product: (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine 1371569-69-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

1371569-69-5, (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidineRelated Search:

(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine

2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-pyrimidine

BETP

Pyrimidine, 2-(ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-

Glucagon Receptor,BETP,inhibit,GCGR,Inhibitor

BETP, 10 mM in DMSO

Glucagon-Like Peptide 1 Receptor Agonist II

1371569-69-5

C20H17F3N2O2S

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds