ChemicalBook > CAS DataBase List > N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide

N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide

Product Name
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide
CAS No.
927822-86-4
Chemical Name
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide
Synonyms
KC7F2;KC7F2, >98%;HIF-1α Translation Inhibitor, KC7F2;N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide;HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem;N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro]-benzenesulfonamide;Benzenesulfonamide, N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-;N,N'-(Disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide);N,N'-(Disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide);N,N'-(2,2'-disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide)
CBNumber
CB52696033
Molecular Formula
C16H16Cl4N2O4S4
Formula Weight
570.38
MOL File
927822-86-4.mol
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N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Property

Boiling point:
708.8±70.0 °C(Predicted)
Density 
1.583±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
9.26±0.50(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1043
Product name
KC7F2
Purity
≥98% (HPLC)
Packaging
1mg
Price
$46.5
Updated
2024/03/01
Sigma-Aldrich
Product number
400088
Product name
HIF-1α Translation Inhibitor, KC7F2
Packaging
25mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
14123
Product name
KC7F2
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
14123
Product name
KC7F2
Purity
≥98%
Packaging
10mg
Price
$89
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1043
Product name
KC7F2
Purity
≥98% (HPLC)
Packaging
5mg
Price
$76.7
Updated
2024/03/01
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N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Chemical Properties,Usage,Production

Description

KC7F2 (927822-86-4) is an inhibitor of HIF-1α (IC50 = 20 μM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of HIF-1α protein synthesis accompanied by suppression of phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1α protein synthesis.

Uses

N,N''-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide is a hypoxia inducible factor (HIF-1) inhibitor which act via down regulation of HIF-1α synthesis.

Uses

N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide is a hypoxia inducible factor (HIF-1) inhibitor which act via down regulation of HIF-1α synthesis.

storage

Store at -20°C

References

1)Narita et al. (2009), Identification of a Novel Small Molecule HIF-1α Translation Inhibitor; Clin. Cancer Res. 15 6128

N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Suppliers

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View Lastest Price from N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide manufacturers

Career Henan Chemical Co
Product
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide 927822-86-4
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

927822-86-4, N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMideRelated Search:

ZM 447439 Geldanamycin TYRPHOSTIN AG 879 Ko 143

  • N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide
  • KC7F2
  • N,N'-(2,2'-disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide)
  • N,N'-(Disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide)
  • HIF-1α Translation Inhibitor, KC7F2
  • 2,5-dichloro-N-[2-[2-[(2,5-dichlorophenyl)sulfonylamino]ethyldisulfanyl]ethyl]benzenesulfonamide
  • HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem
  • KC7F2, >98%
  • Benzenesulfonamide, N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-
  • N,N'-(Disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide)
  • N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro]-benzenesulfonamide
  • 927822-86-4
  • C16H16Cl4N2O4S4
  • Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds