ChemicalBook > CAS DataBase List > 2,6-difluoro-3,5-diMethoxybenzenaMine

2,6-difluoro-3,5-diMethoxybenzenaMine

Product Name: 2,6-difluoro-3,5-diMethoxybenzenaMine
CAS No.: 651734-54-2
Chemical Name: 2,6-difluoro-3,5-diMethoxybenzenaMine
Synonyms: 2,6-Difluoro-3,5-dimethoxyaniline;PEMIGATINIB INT1;Pemetinib intermediate;Chlorpyrifos Impurity 8 (Profenofos);2,6-difluoro-3,5-diMethoxybenzenaMine;2,6-difluoro-3,5-dimethoxy-phenylamine;2,6-difluoro-3,5-dimethoxybenzeneamine;Benzenamine, 2,6-difluoro-3,5-dimethoxy-
CBNumber: CB52702895
Molecular Formula: C8H9F2NO2
Formula Weight: 189.16
MOL File: 651734-54-2.mol

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2,6-difluoro-3,5-diMethoxybenzenaMine Property

Boiling point:: 301.0±37.0 °C(Predicted)
Density: 1.276±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.97±0.10(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C8H9F2NO2/c1-12-4-3-5(13-2)7(10)8(11)6(4)9/h3H,11H2,1-2H3
InChIKey: SUXITUVUFUOAGT-UHFFFAOYSA-N
SMILES: C1(N)=C(F)C(OC)=CC(OC)=C1F

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Safety

HS Code: 2922190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D554150
Product name: 2,6-Difluoro-3,5-dimethoxyaniline
Packaging: 50mg
Price: $130
Updated: 2021/12/16

TRC

Product number: D554150
Product name: 2,6-Difluoro-3,5-dimethoxyaniline
Packaging: 100mg
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: PC908567
Product name: 2,6-Difluoro-3,5-dimethoxyaniline
Purity: 95%
Packaging: 250mg
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 4805AQ
Product name: 2,6-difluoro-3,5-dimethoxyaniline
Packaging: 250mg
Price: $180.8
Updated: 2021/12/16

AK Scientific

Product number: 4805AQ
Product name: 2,6-difluoro-3,5-dimethoxyaniline
Packaging: 1g
Price: $380
Updated: 2021/12/16

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2,6-difluoro-3,5-diMethoxybenzenaMine Chemical Properties,Usage,Production

Uses

2,6-Difluoro-3,5-dimethoxyaniline is an organic compound used primarily as an organic synthesis intermediate and a pharmaceutical intermediate, especially in laboratory research and development and chemical production processes. The compound is a key intermediate in the drug pemigatinib, used to treat certain types of cancer.

Synthesis

651734-57-5

651734-54-2

Tert-butyl 2,6-difluoro-3,5-dimethoxyphenylcarbamate (34.6 g, 0.12 mol) was added to 120 mL of trifluoroacetic acid and stirred until completely dissolved to form a homogeneous solution. The reaction mixture was stirred at room temperature for 30 minutes. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, saturated sodium bicarbonate solution was slowly added to adjust the pH to 8. The resulting suspension was extracted twice with diethyl ether (appropriate amount each time). The organic phases were combined, washed once with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 22 g of 2,6-difluoro-3,5-dimethoxyaniline in 97% yield. The mass spectrum (APCI) showed (M+1)/z of 190.1.

References

[1] Patent: WO2006/38112, 2006, A1. Location in patent: Page/Page column 28
[2] Patent: US2004/19210, 2004, A1. Location in patent: Page 13

2,6-difluoro-3,5-diMethoxybenzenaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,6-difluoro-3,5-diMethoxybenzenaMine manufacturers

Nanjing Fred Technology Co., Ltd

Product: 2,6-Difluoro-3,5-dimethoxybenzenamine 651734-54-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

651734-54-2, 2,6-difluoro-3,5-diMethoxybenzenaMineRelated Search:

2,6-difluoro-3,5-diMethoxybenzenaMine

2,6-Difluoro-3,5-dimethoxyaniline

2,6-difluoro-3,5-dimethoxybenzeneamine

2,6-difluoro-3,5-dimethoxy-phenylamine

PEMIGATINIB INT1

Benzenamine, 2,6-difluoro-3,5-dimethoxy-

Pemetinib intermediate

Chlorpyrifos Impurity 8 (Profenofos)

651734-54-2