ChemicalBook > CAS DataBase List > AZD-5069

AZD-5069

Product Name: AZD-5069
CAS No.: 878385-84-3
Chemical Name: AZD-5069
Synonyms: CS-2808;AZD-5069;CPDD1543;ACT-281959;AZD 5069; AZD5069;AZD-5069, 10 mM in DMSO;AZD-5069; AZD 5069; AZD5069;878385-84-3;inhibit,CXCR,Inhibitor,AZD-5069,AZD5069,AZD 5069,CXC chemokine receptors;N-[2-[(2,3-Difluorobenzyl)thio]-6-[[(2R,3S)-3,4-dihydroxy-2-butyl]oxy]-4-pyrimidinyl]azetidine-1-sulfonamide;N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
CBNumber: CB52702941
Molecular Formula: C18H22F2N4O5S2
Formula Weight: 476.52
MOL File: 878385-84-3.mol

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AZD-5069 Property

Melting point:: 149-152°C
Boiling point:: 680.5±65.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 4.56±0.20(Predicted)
form: Solid
color: White to Off-White

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28297
Product name: AZD 5069
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 28297
Product name: AZD 5069
Packaging: 25mg
Price: $515
Updated: 2024/03/01

Cayman Chemical

Product number: 28297
Product name: AZD 5069
Packaging: 5mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 28297
Product name: AZD 5069
Packaging: 10mg
Price: $238
Updated: 2024/03/01

TRC

Product number: A965309
Product name: AZD-5069
Packaging: 5mg
Price: $130
Updated: 2021/12/16

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AZD-5069 Chemical Properties,Usage,Production

Description

AZD5069 is a potent, selective reversible (time and temperature dependent) antagonist of the human CXCR2 receptor that used for caner treatment.

Uses

AZD-5069 is a potent and selective CXCR2 antagonist with potential as a therapeutic agent in inflammatory conditions.

Biological Activity

AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay). It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.

IC 50

¹²⁵I-IL-8-CXCR2

AZD-5069 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-5069 Suppliers

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878385-84-3, AZD-5069Related Search:

AZD-5069

ACT-281959

CPDD1543

AZD 5069; AZD5069

CS-2808

AZD-5069; AZD 5069; AZD5069;878385-84-3

N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide

1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-

N-(2-(((2,3-Difluorophenyl)methyl)thio)-6-(((1R,2S)-2,3-dihydroxy-1-methylpropyl)oxy)-4-pyrimidinyl)-1-azetidinesulfonamide

inhibit,CXCR,Inhibitor,AZD-5069,AZD5069,AZD 5069,CXC chemokine receptors

AZD-5069, 10 mM in DMSO

N-[2-[(2,3-Difluorobenzyl)thio]-6-[[(2R,3S)-3,4-dihydroxy-2-butyl]oxy]-4-pyrimidinyl]azetidine-1-sulfonamide

878385-84-3

C18H22F2N4O5S2

APIs