AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
- Product Name
- AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
- CAS No.
- 6152-57-4
- Chemical Name
- AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
- Synonyms
- O-Methylviridicatin;Methylviridicatin, O-;3-methoxy-4-phenylquinolin-2(1H)-one;2(1H)-Quinolinone, 3-methoxy-4-phenyl-;AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
- CBNumber
- CB52703746
- Molecular Formula
- C16H13NO2
- Formula Weight
- 251.28
- MOL File
- 6152-57-4.mol
AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solid
N-Bromosuccinimide Price
- Product number
- 19446
- Product name
- O-Methylviridicatin
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $163
- Updated
- 2024/03/01
- Product number
- 19446
- Product name
- O-Methylviridicatin
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $608
- Updated
- 2024/03/01
- Product number
- M3547-32
- Product name
- O-Methylviridicatin
- Packaging
- 1mg
- Price
- $426
- Updated
- 2021/12/16
- Product number
- C3069
- Product name
- O-Methylviridicatin
- Packaging
- 5mg
- Price
- $983
- Updated
- 2021/12/16
- Product number
- C3069
- Product name
- O-Methylviridicatin
- Packaging
- 1mg
- Price
- $263
- Updated
- 2021/12/16
AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Chemical Properties,Usage,Production
Uses
3-O-Methylviridicatin is a metabolite produced by several species of Penicillium. Recently, 3-O-methylviridicatin was shown to be a strong inhibitor of TNFα-induced replication of HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite.
Biological Activity
5 μm: blocks activation of the hiv long terminal repeat by tnf-α in hela cellso-methylviridicatin, a natural derivative of the alkaloid mycotoxin viridicatin, is produced by several species in the genus, penicillium. it is demonstrated that o-methylviridicatin, as an inhibitor, blocks the tumor necrosis factor alpha (tnfα)-induced replication of human immunodeficiency virus (hiv). tnfα increases the binding of the cellular transcription factor nf-κb to the hiv long terminal repeat (ltr), which directly triggers transcription of the latent provirus.
in vitro
o-methylviridicatin had an inhibitory effect on the tnfα-triggered replication of hiv ltr in hela cells. in addition, o-methylviridicatin dose-dependently dampened virus production in the om-10.1 cell line, which was measured by the output of p24 core antigen into the culture medium. it was demonstrated that the suppressive effect of o-methylviridicatin was not reversed even if the concentration of tnfα was increased 10-fold [1].
IC 50
2.5 μm: inhibits virus production in om-10.1 cells (hl-60 promyelocytes infected with hiv-1) treated with tnf-α.
References
[1]. heguy, a., cai, p., meyn, p., houck, d., russo, s., & michitsch, r. et al. isolation and characterization of the fungal metabolite 3-o-methylviridicatin as an inhibitor of tumour necrosis factor-induced human immunodeficiency virus replication. antiviral chemistry and chemotherapy. 1998; 9(2): 149-155.
AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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