ChemicalBook > CAS DataBase List > 2,6-diazabicyclo[3.2.0]heptane

2,6-diazabicyclo[3.2.0]heptane

Product Name
2,6-diazabicyclo[3.2.0]heptane
CAS No.
1204405-68-4
Chemical Name
2,6-diazabicyclo[3.2.0]heptane
Synonyms
2,6-Diazabicyclo[3.2.0]heptane;2-Boc-2,6-diazabicyclo[3.2.0]heptane;tert-Butyl 2,6-diazabicyclo[3.2.0]heptane-2-carboxylate;2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester;2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 1,1-dimethylethyl ester
CBNumber
CB52704167
Molecular Formula
C10H18N2O2
Formula Weight
198.26
MOL File
1204405-68-4.mol
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2,6-diazabicyclo[3.2.0]heptane Property

storage temp. 
Store at 0-8 °C
Appearance
light yellow liquid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B659035
Product name
2-Boc-2,6-diazabicyclo[3.2.0]heptane
Packaging
100mg
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1051907
Product name
2-BOC-2,6-DIAZABICYCLO[3.2.0]HEPTANE
Purity
95.00%
Packaging
5MG
Price
$450.46
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-187
Product name
2-Boc-2,6-diazabicyclo[3.2.0]heptane
Packaging
250mg
Price
$490
Updated
2021/12/16
Synthonix
Product number
B8250
Product name
2-Boc-2,6-diazabicyclo[3.2.0]heptane
Purity
97.0%
Packaging
1g
Price
$1280
Updated
2021/12/16
Matrix Scientific
Product number
113011
Product name
2-Boc-2,6-diazabicyclo[3.2.0]heptane
Packaging
1g
Price
$1565
Updated
2021/12/16
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2,6-diazabicyclo[3.2.0]heptane Chemical Properties,Usage,Production

Uses

2-Boc-2,6-diazabicyclo[3.2.0]heptane is a useful reagent for the preparation of pyrimidine derivatives as KRas G12C inhibitors for treatment of KRas-mediated diseases.

Synthesis

The synthesis of the 2,6-diazabicyclo[3.2.0]heptane scaffold, which comprises a fused azetidine and pyrrolidine system, typically employs an intramolecular photochemical [2+2] cycloaddition as the key ring-forming step. This reaction is performed on a protected N-vinyl-β-lactam or a related unsaturated diamide, in which the vinyl group and a tethered alkene are positioned to form the strained cyclobutane ring of the azetidine moiety upon irradiation. Subsequent deprotection of the nitrogen atoms (e.g., Boc or Cbz removal) yields the free diamine.

2,6-diazabicyclo[3.2.0]heptane Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-diazabicyclo[3.2.0]heptane Suppliers

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1204405-68-4, 2,6-diazabicyclo[3.2.0]heptaneRelated Search:


  • 2-Boc-2,6-diazabicyclo[3.2.0]heptane
  • tert-Butyl 2,6-diazabicyclo[3.2.0]heptane-2-carboxylate
  • 2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester
  • 2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 1,1-dimethylethyl ester
  • 2,6-Diazabicyclo[3.2.0]heptane
  • 1204405-68-4