2,6-diazabicyclo[3.2.0]heptane
- Product Name
- 2,6-diazabicyclo[3.2.0]heptane
- CAS No.
- 1204405-68-4
- Chemical Name
- 2,6-diazabicyclo[3.2.0]heptane
- Synonyms
- 2,6-Diazabicyclo[3.2.0]heptane;2-Boc-2,6-diazabicyclo[3.2.0]heptane;tert-Butyl 2,6-diazabicyclo[3.2.0]heptane-2-carboxylate;2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester;2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 1,1-dimethylethyl ester
- CBNumber
- CB52704167
- Molecular Formula
- C10H18N2O2
- Formula Weight
- 198.26
- MOL File
- 1204405-68-4.mol
2,6-diazabicyclo[3.2.0]heptane Property
- storage temp.
- Store at 0-8 °C
- Appearance
- light yellow liquid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B659035
- Product name
- 2-Boc-2,6-diazabicyclo[3.2.0]heptane
- Packaging
- 100mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CHM1051907
- Product name
- 2-BOC-2,6-DIAZABICYCLO[3.2.0]HEPTANE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $450.46
- Updated
- 2021/12/16
- Product number
- 4H56-1-187
- Product name
- 2-Boc-2,6-diazabicyclo[3.2.0]heptane
- Packaging
- 250mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- B8250
- Product name
- 2-Boc-2,6-diazabicyclo[3.2.0]heptane
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $1280
- Updated
- 2021/12/16
- Product number
- 113011
- Product name
- 2-Boc-2,6-diazabicyclo[3.2.0]heptane
- Packaging
- 1g
- Price
- $1565
- Updated
- 2021/12/16
2,6-diazabicyclo[3.2.0]heptane Chemical Properties,Usage,Production
Uses
2-Boc-2,6-diazabicyclo[3.2.0]heptane is a useful reagent for the preparation of pyrimidine derivatives as KRas G12C inhibitors for treatment of KRas-mediated diseases.
Synthesis
The synthesis of the 2,6-diazabicyclo[3.2.0]heptane scaffold, which comprises a fused azetidine and pyrrolidine system, typically employs an intramolecular photochemical [2+2] cycloaddition as the key ring-forming step. This reaction is performed on a protected N-vinyl-β-lactam or a related unsaturated diamide, in which the vinyl group and a tethered alkene are positioned to form the strained cyclobutane ring of the azetidine moiety upon irradiation. Subsequent deprotection of the nitrogen atoms (e.g., Boc or Cbz removal) yields the free diamine.
2,6-diazabicyclo[3.2.0]heptane Preparation Products And Raw materials
Raw materials
Preparation Products
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