ChemicalBook > CAS DataBase List > tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

Product Name
tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.
1121057-77-9
Chemical Name
tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Synonyms
N-boc-3,4-dihydropiperidine-5-boronic acid pinacol ester;1-Boc-1,4,5,6-tetrahydropyridine-3-boronic Acid Pinacol Ester;tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-t...;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dih;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1;(1-(TERT-BUTOXYCARBONYL)-1,4,5,6-TETRAHYDROPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxyla;ert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2, 3,4-tetrahydropyridine-1-carboxylate
CBNumber
CB52704819
Molecular Formula
C16H28BNO4
Formula Weight
309.21
MOL File
1121057-77-9.mol
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tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Property

Boiling point:
339.6±52.0 °C(Predicted)
Density 
1.05±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
-0.31±0.40(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
B710065
Product name
tert-Butyl5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Packaging
50mg
Price
$155
Updated
2021/12/16
Synthonix
Product number
T10684
Product name
tert-butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Purity
97.0%
Packaging
5g
Price
$1770
Updated
2021/12/16
Synthonix
Product number
T10684
Product name
tert-butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Purity
97.0%
Packaging
10g
Price
$2950
Updated
2021/12/16
Synthonix
Product number
T10684
Product name
tert-butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Purity
97.0%
Packaging
500mg
Price
$390
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BOR0025794
Product name
TERT-BUTYL-5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,4-TETRAHYDROPYRIDINE-1-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$452.65
Updated
2021/12/16
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tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Chemical Properties,Usage,Production

Synthesis

149108-74-7

73183-34-3

1121057-77-9

Step 4. tert-Butyl 5-(((trifluoromethyl)sulfonyl)oxy)-3,4-dihydropyridine-1(2H)-carboxylate (1.45 g, 4.38 mmol) and pinacol ester of bisboronic acid (1.223 g, 4.81 mmol) were dissolved in dioxane (24 mL). To this solution was added potassium acetate (1.289 g, 13.13 mmol) and PdCl2(dppf)-CH2Cl2 adduct (0.107 g, 0.131 mmol). The reaction mixture was purged for 5 min under nitrogen protection and subsequently heated in an oil bath at 80 °C overnight. After completion of the reaction, the mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast chromatography using a 0-30% ethyl acetate/heptane gradient elution to afford the target product tert-butyl 5-boronic acid pinacol esteryl-3,4-dihydropyridine-1(2H)-carboxylate as a highly viscous liquid (1.2 g, 89% yield).LCMS (m/z): 254.1 (MH+ - tBu), retention time 1.21 min.

References

[1] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 385; 386; 388; 389
[2] Patent: WO2018/203256, 2018, A1. Location in patent: Page/Page column 36
[3] Patent: US2013/102601, 2013, A1. Location in patent: Paragraph 184
[4] Patent: US2013/102600, 2013, A1. Location in patent: Page/Page column 0169; 0171
[5] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 44-45

tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate manufacturers

Career Henan Chemical Co
Product
tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate 1121057-77-9
Price
US $2.00/KG
Min. Order
1KG
Purity
99
Supply Ability
100kg
Release date
2020-01-07

1121057-77-9, tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylateRelated Search:

tert-Butyl 6-broMo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate Tert-Butyl7-oxo-3-azabicyclo[3.3.1]nonane-3-carboxylate tert-Butyl N-[(1-aMinocyclobutyl)Methyl]carbaMate tert-butyl (trans-3-aMino-3-Methylcyclobutyl)carbaMate 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyrimidine Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

  • tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1
  • tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxyla
  • N-boc-3,4-dihydropiperidine-5-boronic acid pinacol ester
  • tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate
  • (1-(TERT-BUTOXYCARBONYL)-1,4,5,6-TETRAHYDROPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER
  • tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dih
  • 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
  • tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-t...
  • tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2, 3,4-tetrahydropyridine-1-carboxylate
  • 1-Boc-1,4,5,6-tetrahydropyridine-3-boronic Acid Pinacol Ester
  • 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
  • ert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
  • tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate - [T10684]
  • 1121057-77-9
  • Organic boronic acid