CDDO-EA

Product Name: CDDO-EA
CAS No.: 932730-51-3
Chemical Name: CDDO-EA
Synonyms: TP319;TP 319;RTA405;TP-319);CDDO-EA;RTA 405;RTA-405;CS-1305;CDDO ethyl amide;Bardoxolone ethyl amide
CBNumber: CB52705078
Molecular Formula: C33H46N2O3
Formula Weight: 518.73
MOL File: 932730-51-3.mol

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CDDO-EA Property

Boiling point:: 670.7±55.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 34 mg/mL (65.54 mM)
form: Powder
pka: 16.21±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611797
Product name: CDDO-EA
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611797
Product name: CDDO-EA
Packaging: 50mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611797
Product name: CDDO-EA
Packaging: 100mg
Price: $2512.6
Updated: 2021/12/16

Crysdot

Product number: CD31000205
Product name: CDDO-EA
Purity: 98+%
Packaging: 5mg
Price: $245
Updated: 2021/12/16

Crysdot

Product number: CD31000205
Product name: CDDO-EA
Purity: 98+%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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CDDO-EA Chemical Properties,Usage,Production

Biological Activity

CDDO-EA is a NF-E2-related factor 2/antioxidant response element (Nrf2/ARE) activator.

in vitro

CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. It is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.

in vivo

The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%).

target

Nrf2/ARE

CDDO-EA Preparation Products And Raw materials

Raw materials

Preparation Products

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CDDO-EA Suppliers

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932730-51-3, CDDO-EARelated Search:

CDDO-EA

Bardoxolone ethyl amide

CDDO ethyl amide

CDDO ETHYL AMIDE;RTA405;TP319;RTA 405;TP 319;RTA-405;TP-319

CDDO-EA (CDDO ethyl amide

RTA 405

RTA405

RTA-405

TP 319

TP319

TP-319)

CDDO EA, RTA 405, tP 319

CS-1305

Oleana-1,9(11)-dien-28-amide, 2-cyano-N-ethyl-3,12-dioxo-

932730-51-3