GDC-0834 (RaceMate)

Product Name: GDC-0834 (RaceMate)
CAS No.: 1133432-46-8
Chemical Name: GDC-0834 (RaceMate)
Synonyms: CS-1264;GDC0834; GDC 0834;GDC-0834 (RaceMate);GDC 0834 Racemate,GDC0834 Racemate;N-[3-[6-[[4-(1,4-Dimethyl-3-oxo-2-piperazinyl)phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide;N-(3-(6-((4-(1,4-Dimethyl-3-oxopiperazin-2-yl)phenyl)amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide;Benzo[b]thiophene-2-carboxamide, N-[3-[6-[[4-(1,4-dimethyl-3-oxo-2-piperazinyl)phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydro-
CBNumber: CB52705083
Molecular Formula: C33H36N6O3S
Formula Weight: 596.74
MOL File: 1133432-46-8.mol

More

Less

GDC-0834 (RaceMate) Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 49 mg/mL (82.11 mM)
form: Solid
pka: 12.46±0.70(Predicted)
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-3124
Product name: GDC-0834Racemate
Purity: 98.64%
Packaging: 5mg
Price: $216
Updated: 2021/12/16

ChemScene

Product number: CS-3124
Product name: GDC-0834Racemate
Purity: 98.64%
Packaging: 10mg
Price: $322
Updated: 2021/12/16

ChemScene

Product number: CS-3124
Product name: GDC-0834Racemate
Purity: 98.64%
Packaging: 50mg
Price: $871
Updated: 2021/12/16

Crysdot

Product number: CD31004512
Product name: GDC-0834Racemate
Purity: 98+%
Packaging: 5mg
Price: $125
Updated: 2021/12/16

Crysdot

Product number: CD31004512
Product name: GDC-0834Racemate
Purity: 98+%
Packaging: 10mg
Price: $186
Updated: 2021/12/16

More

Less

GDC-0834 (RaceMate) Chemical Properties,Usage,Production

Uses

GDC-0834 Racemate is the racemate form of GDC-0834, which is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 and 6.4 nM in biochemical and cellular assays, respectively. IC50 value: 5.9 nM/6.4 nM(biochemical/cellular assay) [1] Target: BTK in vitro: GDC-0834 inhibited BTK with an in vitro IC(50) of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC(50) of 1.1 and 5.6 μM in mouse and rat, respectively [1]. in vivo: Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology [1]. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. Uncertainty in human pharmacokinetic prediction and high interest in a BTK inhibitor for clinical evaluation prompted an investigational new drug strategy, in which GDC-0834 was rapidly advanced to a single-dose human clinical trial. GDC-0834 plasma concentrations in humans were below the limit of quantitation (<1 ng/ml) in most samples from the cohorts dosed orally at 35 and 105 mg [2].

References

[1] Liu L, et al. Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. J DOI:10.1124/jpet.111.181545
[2] Liu L, et al. Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor. Drug Metab Dispos. 2011 Oct;39(10):1840-9. DOI:10.1124/dmd.111.040840

GDC-0834 (RaceMate) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GDC-0834 (RaceMate) Suppliers

China 22 United States 7 Global 29

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

1133432-46-8, GDC-0834 (RaceMate)Related Search:

CS-1264

GDC-0834 (RaceMate)

N-[3-[6-[[4-(1,4-Dimethyl-3-oxo-2-piperazinyl)phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide

GDC0834; GDC 0834

Benzo[b]thiophene-2-carboxamide, N-[3-[6-[[4-(1,4-dimethyl-3-oxo-2-piperazinyl)phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydro-

GDC 0834 Racemate,GDC0834 Racemate

N-(3-(6-((4-(1,4-Dimethyl-3-oxopiperazin-2-yl)phenyl)amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide

1133432-46-8

C33H36N6O3S