CUDC-427

Product Name: CUDC-427
CAS No.: 1446182-94-0
Chemical Name: CUDC-427
Synonyms: GDC0917;GDC 0917;CUDC-427;GDC-0917;CUDC 427,CUDC427;GDC-0917 (CUDC-427);CUDC-427 (GDC-0917);CUDC-427, 10 mM in DMSO;L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[2-(2-oxazolyl)-4-phenyl-5-thiazolyl]-
CBNumber: CB52716179
Molecular Formula: C29H36N6O4S
Formula Weight: 564.7
MOL File: 1446182-94-0.mol

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CUDC-427 Property

Density: 1.281±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 61 mg/mL (108.02 mM)
form: Solid
pka: 11.78±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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CUDC-427 Chemical Properties,Usage,Production

Uses

CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.

in vivo

GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species^[1].

References

[1] Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41(12):2104-13. DOI:10.1124/dmd.113.053926

CUDC-427 Preparation Products And Raw materials

Raw materials

Preparation Products

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CUDC-427 Suppliers

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1446182-94-0, CUDC-427Related Search:

CUDC-427

GDC 0917

GDC0917

GDC-0917

L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[2-(2-oxazolyl)-4-phenyl-5-thiazolyl]-

CUDC-427 (GDC-0917)

GDC-0917 (CUDC-427)

CUDC 427,CUDC427

CUDC-427, 10 mM in DMSO

1446182-94-0

C29H36N6O4S