TCS 401

Product Name: TCS 401
CAS No.: 243966-09-8
Chemical Name: TCS 401
Synonyms: TCS 401 HCl;TCS-401;TCS401;TCS-401 Hydrochloride;TCS 401, 10 mM in DMSO;TCS-401,inhibit,TCS 401,Inhibitor,TCS401,Phosphatase;2-(Carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
CBNumber: CB52716366
Molecular Formula: C10H11ClN2O5S
Formula Weight: 306.72
MOL File: 243966-09-8.mol

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TCS 401 Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: 0.1 M NaOH: 5 mg/ml
form: A crystalline solid
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20393
Product name: TCS 401
Purity: ≥95%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 20393
Product name: TCS 401
Purity: ≥95%
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 20393
Product name: TCS 401
Purity: ≥95%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 20393
Product name: TCS 401
Purity: ≥95%
Packaging: 25mg
Price: $475
Updated: 2024/03/01

TRC

Product number: T127305
Product name: TCS401
Packaging: 10mg
Price: $210
Updated: 2021/12/16

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TCS 401 Chemical Properties,Usage,Production

Uses

TCS 401 binds the functional spine PTP1B and inhibits its function in PTP1B related diseases like cancer, obesity and diabetes.

Biological Activity

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B), which plays a key role in the negative regulation of the insulin signaling pathway, contributing to insulin resistance. It exhibited Ki values of 290 nM for PTP1B, with greater than 100-fold or more selectivity compared to other phosphatases. Inhibition of PTP1B by TCS 401 has been shown to sensitize the insulin signaling pathway and increase dopamine release in response to insulin. TCS-401 has also been shown to promote endothelial cell motility and to induce differentiation of retinal pigment epithelial cells toward improved contractility and motility.

storage

Desiccate at RT

TCS 401 Preparation Products And Raw materials

Raw materials

Preparation Products

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TCS 401 Suppliers

China 33 India 1 United Kingdom 1 United States 6 USA 1 Global 42

Haoyuan Chemexpress Co., Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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Musechem

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Shenzhen Regent Biochemical Technology Co., Ltd.

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243966-09-8, TCS 401Related Search:

TCS-401;TCS401

TCS 401 HCl

TCS-401 Hydrochloride

TCS-401,inhibit,TCS 401,Inhibitor,TCS401,Phosphatase

2-(Carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride

TCS 401, 10 mM in DMSO

243966-09-8