3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Product Name: 3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
CAS No.: 507462-88-6
Chemical Name: 3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
Synonyms: 4-Hydroxy-2-methoxyphenylboronic acid pinacol ester;3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol;Phenol, 3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB52719059
Molecular Formula: C13H19BO4
Formula Weight: 250.1
MOL File: 507462-88-6.mol

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3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol Property

Boiling point:: 386.4±32.0 °C(Predicted)
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 9.28±0.35(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BOR0006648
Product name: 3-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
Purity: 95.00%
Packaging: 5MG
Price: $497.21
Updated: 2021/12/16

AK Scientific

Product number: 7009AB
Product name: 3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
Packaging: 1g
Price: $506
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0006648
Product name: 3-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
Purity: 95.00%
Packaging: 1G
Price: $1229.55
Updated: 2021/12/16

Alichem

Product number: 507462886
Product name: 3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
Packaging: 5g
Price: $1411.2
Updated: 2021/12/16

Crysdot

Product number: CD12067048
Product name: 3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
Purity: 95+%
Packaging: 5g
Price: $1426
Updated: 2021/12/16

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3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol Chemical Properties,Usage,Production

Uses

3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is a useful reagent in the preparation of ethylidenedihydroindolones, that functions as potential checkpoint 1 kinase inhibitors for abrogating the G2 DNA damage checkpoint arrest.

Synthesis

102127-34-4

73183-34-3

507462-88-6

4-Bromo-3-methoxyphenol (5 g, 24.75 mmol) and pinacol ester of bisboronic acid (9.43 g, 37.13 mmol) were dissolved in dioxane (50 mL), and anhydrous potassium acetate (6.1 g, 74.25 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride dichloromethane complex (2 g. 2.47 mmol). The reaction mixture was heated to 80 °C and stirred for 16 h under nitrogen protection. After completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with ethyl acetate (50 mL) and filtered through diatomaceous earth. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent ratio of petroleum ether: ethyl acetate = 1:1) to afford the target product, 3-methoxy-4-boronic acid pinacol ester phenol (17-c), as a pale yellow solid (2.8 g, 45% yield). The product was analyzed by mass spectrometry (LC-MS, ESI): m/z = 251 [M + H]+.

References

[1] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0283-0284
[2] Patent: WO2014/28459, 2014, A1. Location in patent: Page/Page column 107; 108

3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol Suppliers

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507462-88-6, 3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolRelated Search:

3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

4-Hydroxy-2-methoxyphenylboronic acid pinacol ester

Phenol, 3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

507462-88-6