ChemicalBook > CAS DataBase List > Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
- Product Name
- Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
- CAS No.
- 1246298-62-3
- Chemical Name
- Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
- Synonyms
- Kdo2-Lipid A;Kdo2-Lipid A (KLA);Kdo2-Lipid A ammonium;Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt);DI[3-DEOXY-D-MANNO-OCTULOSONYL]-LIPID A (AMMONIUM SALT);KDO2-LIPID A;Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution;O-3-Deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-4)-O-3-deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-6)-O-2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-beta-D-glucopyranosyl-(1-6)-2-deoxy-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] ammonium salt (1:4)
- CBNumber
- CB52719776
- Molecular Formula
- C110H214N6O39P2
- Formula Weight
- 2306.840482
- MOL File
- 1246298-62-3.mol
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Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Property
- storage temp.
- -20°C
- form
- solid
- color
- White to off-white
- biological source
- Escherichia coli
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2430
- Product name
- Kdo2-Lipid A (KLA)
- Purity
- ≥90% (HPLC)
- Packaging
- 1mg
- Price
- $193
- Updated
- 2024/03/01
Usbiological
- Product number
- 044977
- Product name
- Kdo2-Lipid A
- Packaging
- 1mg
- Price
- $375
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 108090
- Product name
- Di[3-deoxy-D-manno-octulosonyl]-lipidAsodiumsalt-0.5mg/mlindoubledistilledwater
- Packaging
- 1mg
- Price
- $759
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- OD29173
- Product name
- Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution
- Packaging
- 1mg
- Price
- $995
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- OD29173
- Product name
- Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution
- Packaging
- 2mg
- Price
- $1940
- Updated
- 2021/12/16
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Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Chemical Properties,Usage,Production
Uses
Kdo2-Lipid A (KLA) is a nearly homogeneous Re lipopolysaccharide (LPS) substracture with endotoxin activity equal to tha of native LPS. KLA is comparable to LPS and its activity is reduced by >10^3 in cells fro TLR-4 deficient mice.
Uses
Kdo2-Lipid A (KLA) has been used:
- as a toll like receptor (TLR) ligand source in immortalized murine macrophage culture media
- in 2H-,13C-,15N-labeled OprHΔL1ΔL4 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) micelles, to determine the specific residues of OprHΔL1ΔL4 interacting with lipopolysaccharides (LPS) source
- as a component of LPS stock to study its role in lipopolysaccharide induced prion protein conversion
General Description
3-deoxy-D-manno-octulosonic acid (Kdo2-Lipid A) is the essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 (TLR4) and myeloid differentiation protein 2 (MD2). Therefore, Kdo2-lipid A is an important stimulator for studying the mechanism of the innate immune system and for developing bacterial vaccine adjuvants. Kdo2 Lipid A/TLR4 antagonists can also be applied in anti-inflammatory interventions. Kdo2-lipid A, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. Kdo2-Lipid A has been used in animal atherosclerosis model.
Biochem/physiol Actions
Kdo2-Lipid A might be useful to stimulate inflammatory response.
in vivo
KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats[1].
| Animal Model: | Rats (Male Holzman Sprague-Dawley, 300–400 g) [1] |
| Dosage: | 0.1 to 10 μg |
| Administration: | I.T.; 0.1-10 μg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A. |
| Result: | Intrathecal injection of 1 μg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A. |
IC 50
TLR4
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
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Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Suppliers
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