(E)-2-oxopropanal oxime
- Product Name
- (E)-2-oxopropanal oxime
- CAS No.
- 306-44-5
- Chemical Name
- (E)-2-oxopropanal oxime
- Synonyms
- PYRUVALDOXIME;oximinoacetone;pyruvaldehydoxim;ISONITROSOACETONE;Acetone, isonitroso-;2-oxopropanal-1-oxime;3-hydroxyimino-aceton;3-hydroxyiminoacetone;monoizonitrozoacetone;PYRUVALDEHYDE 1-OXIME
- CBNumber
- CB5272301
- Molecular Formula
- C3H5NO2
- Formula Weight
- 87.08
- MOL File
- 306-44-5.mol
(E)-2-oxopropanal oxime Property
- Melting point:
- 69°
- Boiling point:
- 160.87°C (rough estimate)
- Density
- 1.0744
- refractive index
- 1.4940 (estimate)
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pK (25°) 8.39
- color
- Brown
- EPA Substance Registry System
- Propanal, 2-oxo-, 1-oxime (306-44-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I821863
- Product name
- Isonitrosoacetone
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- I821863
- Product name
- Isonitrosoacetone
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 452614
- Product name
- Isonitrosoacetone
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- A450392
- Product name
- 2-Oxopropanaloxime
- Purity
- 95%
- Packaging
- 25g
- Price
- $438
- Updated
- 2021/12/16
- Product number
- A1475545
- Product name
- 2-Oxopropanaloxime
- Purity
- 98+%
- Packaging
- 25g
- Price
- $438
- Updated
- 2021/12/16
(E)-2-oxopropanal oxime Chemical Properties,Usage,Production
Uses
(E)-2-oxopropanal oxime can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes.
Preparation
To a well-stirred, ice-cooled solution of 5.8 gm (0.1 mole) of acetone in 30 ml of glacial acetic acid is added dropwise a concentrated aqueous solution containing 15 gm of sodium nitrite. Stirring at 0°C is continued for 45 min, then 100 ml of water is added and the crude product is extracted with ether.
The ether extracts are combined, washed repeatedly with 10 ml portions of water, and dried with sodium sulfate. The ether is evaporated off under reduced pressure and the residue is dried on a porous plate. After recrys-tallization from benzene, 6 gm (69%) of the product is isolated, m.p. 65°C.
Synthesis
under the condition of the ice, to 1000 ml three port successively added in the bottle KOH (58.35g, 1 . 16eq, 1 . 04mol) and 585 ml water, the reaction system is cooled to 0 °C, adding to the reaction system (103.61g, 1eq, 0.892mol), after stirring at room temperature add 24h; once again the reaction system is cooled to 0 °C, in the reaction system by adding NaNO2(71.76g, 1 . 16eq, 1 . 04mol), the reaction system to maintain 0 °C, to wherein the dropwise H2SO4(50%), the for PH 4-5 (adding sulphuric acid to the volume to the final system is PH), stir at room temperature 2h, this will produce a large amount of gas in the process, a white precipitate, then in to the system by adding NaOH (35%) solution, the for PH 9-10, finally in the reaction system by adding 100 ml of toluene, the organic phase and aqueous phase separation, is added to the aqueous phase H2SO4(50%) the adjusted to PH 5-6, ethyl acetate (3*100 ml) extraction, anhydrous sodium sulfate for drying, can be obtained turns on lathe does white solid 61 . 3g (yield 79%).
(E)-2-oxopropanal oxime Preparation Products And Raw materials
Raw materials
Preparation Products
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