1-(4-BroMo-3-Methoxyphenyl)ethanone
- Product Name
- 1-(4-BroMo-3-Methoxyphenyl)ethanone
- CAS No.
- 50870-44-5
- Chemical Name
- 1-(4-BroMo-3-Methoxyphenyl)ethanone
- Synonyms
- 4'-Bromo-3'-methoxyacetophenone;1-(4-BroMo-3-Methoxyphenyl)ethanone;Ethanone, 1-(4-bromo-3-methoxyphenyl)-;1-(4-bromo-3-methoxyphenyl)ethan-1-one;1-(4-Bromo-3-methoxyphenyl)ethanone - [B93211]
- CBNumber
- CB52723353
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 50870-44-5.mol
1-(4-BroMo-3-Methoxyphenyl)ethanone Property
- Melting point:
- 31.5-32.0 °C
- Boiling point:
- 292.7±25.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- Light yellow to yellow Liquid
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- X3797
- Product name
- 1-(4-Bromo-3-methoxyphenyl)ethanone
- Packaging
- 1g
- Price
- $336
- Updated
- 2021/12/16
- Product number
- OR53079
- Product name
- 4'-Bromo-3'-methoxyacetophenone
- Packaging
- 250mg
- Price
- $372
- Updated
- 2021/12/16
- Product number
- 2617-9-37
- Product name
- 4'-Bromo-3'-methoxyacetophenone
- Packaging
- 250mg
- Price
- $410
- Updated
- 2021/12/16
- Product number
- OR53079
- Product name
- 4'-Bromo-3'-methoxyacetophenone
- Packaging
- 1g
- Price
- $795
- Updated
- 2021/12/16
- Product number
- 2617-9-37
- Product name
- 4'-Bromo-3'-methoxyacetophenone
- Packaging
- 1g
- Price
- $877
- Updated
- 2021/12/16
1-(4-BroMo-3-Methoxyphenyl)ethanone Chemical Properties,Usage,Production
Synthesis
19056-40-7
127-09-3
50870-44-5
General procedure for the synthesis of 1-(4-bromo-3-methoxyphenyl)ethanone from 4-bromo-3-methoxyaniline and sodium acetate: commercially available 4-bromo-3-methoxyaniline (10.2 g, 50.6 mmol) was dissolved in a mixture of concentrated hydrochloric acid and water (11 mL of concentrated hydrochloric acid/25 mL of water) that had been pre-cooled to -5 °C, and sodium nitrite (3.48 g) was added in batches. The reaction mixture was stirred at 0 °C for 1 h, followed by slow transfer to an aqueous solution (20.5 mL) containing acetaldoxime (6.02 g), copper sulfate pentahydrate (2.52 g) and sodium acetate trihydrate (36.64 g) at 0 °C. The resulting mixture was stirred between 0°C and 10°C for 2 hours, then 37% hydrochloric acid (23 mL) was added and the mixture was refluxed for 2 hours. After the reaction mixture was cooled to room temperature, it was extracted with heptane and the organic phase was dried with anhydrous magnesium sulfate. The organic solvent was removed by vacuum evaporation to give a residue which was purified by silica gel column chromatography (eluent was dichloromethane/cyclohexane in a gradual ratio from 50/50 to 90/10). Intermediate 681 (5.9 g) in amorphous solid form was finally obtained.1H NMR (400 MHz; CDCl3): δ 7.55 (d, 1H); 7.50 (d, 1H); 7.40 (dd, 1H); 3.95 (s, 3H); 2.60 (s, 3H).IR (cm-1): 1681.
References
[1] Patent: US2017/137385, 2017, A1. Location in patent: Paragraph 0260; 0261; 0262; 0263
1-(4-BroMo-3-Methoxyphenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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