(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(3,4-dihydroxyphenyl)propanoate
- Product Name
- (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(3,4-dihydroxyphenyl)propanoate
- CAS No.
- 37169-36-1
- Chemical Name
- (S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(3,4-dihydroxyphenyl)propanoate
- Synonyms
- Boc-DOPA-OMe;Boc-3-Hydroxy-L-Tyrosine methyl ester;N-Boc-3-Hydroxy-L-Tyrosine methyl ester;Methyl (S)-2-(Boc-amino)-3-(3,4-dihydroxyphenyl)propanoate;L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-hydroxy-, methyl ester;(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(3,4-dihydroxyphenyl)propanoate
- CBNumber
- CB52723429
- Molecular Formula
- C15H21NO6
- Formula Weight
- 311.33
- MOL File
- 37169-36-1.mol
(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(3,4-dihydroxyphenyl)propanoate Property
- Melting point:
- 138 °C(Solv: methanol (67-56-1); water (7732-18-5))
- Boiling point:
- 502.7±50.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Solid
- pka
- 9.62±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AK163878
- Product name
- (S)-Methyl2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $8
- Updated
- 2021/12/16
- Product number
- AS49032
- Product name
- (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate
- Purity
- 97% ee
- Packaging
- 5G
- Price
- $86
- Updated
- 2021/12/16
- Product number
- 5841CV
- Product name
- (S)-Methyl2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 5841CV
- Product name
- (S)-Methyl2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate
- Packaging
- 5g
- Price
- $141
- Updated
- 2021/12/16
- Product number
- AS49032
- Product name
- (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate
- Purity
- 97% ee
- Packaging
- 25g
- Price
- $288
- Updated
- 2021/12/16
(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(3,4-dihydroxyphenyl)propanoate Chemical Properties,Usage,Production
Uses
(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate is a tyrosine derivative[1].
Synthesis
24424-99-5
1421-65-4
37169-36-1
The general procedure for the synthesis of (S)-(2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoic acid methyl ester from di-tert-butyl dicarbonate and (S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid methyl ester hydrochloride was carried out as follows: under ice-bath conditions, a mixture of (S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid methyl ester hydrochloride (0.9 g 3.6 mmol) solution of THF (6.5 mL), saturated aqueous NaHCO3 solution (6.5 mL) and di-tert-butyl dicarbonate (0.87 g, 4.0 mmol) were added sequentially to the reaction flask. Subsequently, additional THF (4.0 mL) was added slowly. The reaction mixture was stirred at room temperature for 1 h, after which the organic solvent was removed by rotary evaporation. The aqueous phase was extracted three times with CH2Cl2 and the combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated to dryness. The residue was ground with Et2O and allowed to stand at low temperature. Finally, the target product (S)-(2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoic acid methyl ester was obtained by vacuum filtration.
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368
(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(3,4-dihydroxyphenyl)propanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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