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NMS-P715

Product Name
NMS-P715
CAS No.
1202055-32-0
Chemical Name
NMS-P715
Synonyms
NMS-P715 (NMS P715;NMS P715; NMS-P 715; NMS P715; NMS-P 715;Monopolar spindle 1,Mps1,NMS P715,NMS-P715,inhibit,NMSP715,Inhibitor,NMS-P-715;1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide, N-(2,6-diethylphenyl)-4,5-dihydro-1-methyl-8-[[4-[[(1-methyl-4-piperidinyl)amino]carbonyl]-2-(trifluoromethoxy)phenyl]amino]-
CBNumber
CB52725630
Molecular Formula
C35H39F3N8O3
Formula Weight
676.73
MOL File
1202055-32-0.mol
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NMS-P715 Property

Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
pka
11.75±0.70(Predicted)
color 
White to off-white
InChIKey
JFOAJUGFHDCBJJ-UHFFFAOYSA-N
SMILES
CN(N=C1C(NC2=C(CC)C=CC=C2CC)=O)C3=C1CCC4=C3N=C(NC5=CC=C(C(NC6CCN(C)CC6)=O)C=C5OC(F)(F)F)N=C4
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Safety

WGK Germany 
WGK 2
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
475949
Product name
MPS1 Inhibitor, NMS-P715
Purity
The MPS1 Inhibitor, NMS-P715 controls the biological activity of MPS1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Packaging
5 mg
Price
$270
Updated
2026/03/19
ChemScene
Product number
CS-3396
Product name
NMS-P715
Purity
>99.0%
Packaging
10mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-3396
Product name
NMS-P715
Purity
>99.0%
Packaging
50mg
Price
$1008
Updated
2021/12/16
ChemScene
Product number
CS-3396
Product name
NMS-P715
Purity
>99.0%
Packaging
100mg
Price
$1680
Updated
2021/12/16
ChemScene
Product number
CS-3396
Product name
NMS-P715
Purity
>99.0%
Packaging
5mg
Price
$190
Updated
2021/12/16
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NMS-P715 Chemical Properties,Usage,Production

Uses

NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.

in vivo

NMS-P715 (10 mg/kg) exhibits an oral bioavailability of 37% and good pharmacokinetic properties in nude mice bearing subcutaneous implanted human tumor cell xenografts. NMS-P715 (90 mg/kg, p.o.) is well tolerated and cuases no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model. NMS-P715 (100 mg/kg, p.o.) inhibits the tumor growth by appr 43% in the A375 melanoma xenograft model[1].

IC 50

Mps1: 182 nM (IC50); CK2: 5.7 μM (IC50); MELK: 6.01 μM (IC50); NEK6: 6.02 μM (IC50)

References

[1] Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64. DOI:10.1158/0008-5472.CAN-10-2101
[2] Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315. DOI:10.1158/1535-7163.MCT-13-0324

NMS-P715 Preparation Products And Raw materials

Raw materials

Preparation Products

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NMS-P715 Suppliers

China 33 United States 6 Global 39
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai XingMo Biotechnology Co., Ltd.
Tel
+86 13524779951; 13524779951
Fax
QQ: 2075692521
Email
2075692521@qq.com
Country
China
ProdList
294
Advantage
55
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58

1202055-32-0, NMS-P715Related Search:


  • NMS P715; NMS-P 715; NMS P715; NMS-P 715
  • 1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide, N-(2,6-diethylphenyl)-4,5-dihydro-1-methyl-8-[[4-[[(1-methyl-4-piperidinyl)amino]carbonyl]-2-(trifluoromethoxy)phenyl]amino]-
  • Monopolar spindle 1,Mps1,NMS P715,NMS-P715,inhibit,NMSP715,Inhibitor,NMS-P-715
  • NMS-P715 (NMS P715
  • 1202055-32-0
  • C35H39F3N8O3