Methyl 1-(Boc-aMino)-4-oxo-cyclohexanecarboxylate
- Product Name
- Methyl 1-(Boc-aMino)-4-oxo-cyclohexanecarboxylate
- CAS No.
- 191111-27-0
- Chemical Name
- Methyl 1-(Boc-aMino)-4-oxo-cyclohexanecarboxylate
- Synonyms
- Methyl 1-(Boc-aMino)-4-oxo-cyclohexanecarboxylate;METHYL 1-((TERT-BUTOXYCARBONYL)AMINO)-4-OXOCYCLOHEXANECARBOXYLATE;methyl 1-{[(tert-butoxy)carbonyl]amino}-4-oxocyclohexane-1-carboxylate;Methyl 1-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxocyclohexanecarboxylate;methyl 1-{[(tert-butoxy)carbonyl]amino}-4-oxocyclohexane-1-carboxylate - [M84190];1-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxocyclohexanecarboxylic acid methyl ester;Cyclohexanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, methyl ester
- CBNumber
- CB52730517
- Molecular Formula
- C13H21NO5
- Formula Weight
- 271.31
- MOL File
- 191111-27-0.mol
Methyl 1-(Boc-aMino)-4-oxo-cyclohexanecarboxylate Property
- Boiling point:
- 386.6±42.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Store at 0-8 °C
- pka
- 10.20±0.20(Predicted)
- Appearance
- White Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A-5983
- Product name
- Methyl1-(Boc-amino)-4-oxo-cyclohexanecarboxylate
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- A-5983
- Product name
- Methyl1-(Boc-amino)-4-oxo-cyclohexanecarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CM250804
- Product name
- Methyl1-((tert-butoxycarbonyl)amino)-4-oxocyclohexanecarboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $643
- Updated
- 2021/12/16
- Product number
- CD13019429
- Product name
- Methyl1-((tert-butoxycarbonyl)amino)-4-oxocyclohexanecarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $681
- Updated
- 2021/12/16
- Product number
- SC-66788
- Product name
- Methyl1-(tert-butoxycarbonylamino)-4-oxocyclohexanecarboxylate
- Purity
- 95
- Packaging
- 10g
- Price
- $3333
- Updated
- 2021/12/16
Methyl 1-(Boc-aMino)-4-oxo-cyclohexanecarboxylate Chemical Properties,Usage,Production
Synthesis
191110-78-8
191111-27-0
The general procedure for the synthesis of methyl 1-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexane-1-carboxylate from methyl 1-((tert-butoxycarbonyl)amino)-4-oxocyclohexanecarboxylate was as follows: tetrapropylammonium perruthenate (26 mg, 0.075 mmol) was added in a single step to stirred 1-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexane-1-carboxylate methyl ester (410 mg, 1.5 mmol), N-methylmorpholine-N-oxide (264 mg, 2.25 mmol), and 4A molecular sieves (750 mg) in a mixture of 15 mL of 10% acetonitrile in dichloromethane solution. The reaction was carried out under argon protection. The reaction mixture was stirred for 1 h at room temperature and then the solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: hexane solution of 30% ethyl acetate) to afford 372 mg (91.6% yield) of the target product methyl 1-((tert-butoxycarbonyl)amino)-4-oxocyclohexanecarboxylate as a white solid.1H NMR (CD3OD) δ: 1.43 [9H, s, -C(CH3)3], 2.32-2.42 (8H, m, 4×-CH2-), 3.74 (3H, s, COOCH3), 5.04 (1H, br, NH).
References
[1] Patent: US2006/292073, 2006, A1. Location in patent: Page/Page column 12
Methyl 1-(Boc-aMino)-4-oxo-cyclohexanecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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