EPZ011969

Product Name: EPZ011969
CAS No.: 1598383-40-4
Chemical Name: EPZ011969
Synonyms: CS-1609;CS-2079;EPZ011989;EPZ011969;EPZ011989;EPZ-011989;EPZ011989,inhibit,Histone Methyltransferase,Inhibitor,EPZ 011989,EPZ-011989;N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-ynyl)benzamide;N-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-3-(ETHYL((TRANS)-4-((2-METHOXYETHYL)(METHYL)AMINO)CYCLOHEXYL)AMINO)-2-METHYL-5-(3-MORPHOLINOPROP-1-YN-1-YL)BENZAMIDE;N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]benzamide;Benzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-
CBNumber: CB52741562
Molecular Formula: C35H51N5O4
Formula Weight: 605.81
MOL File: 1598383-40-4.mol

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EPZ011969 Property

Boiling point:: 756.7±60.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:55.0(Max Conc. mg/mL);90.79(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);16.51(Max Conc. mM)
Ethanol:60.0(Max Conc. mg/mL);99.04(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.83(Max Conc. mM)
form: A crystalline solid
pka: 11.88±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19161
Product name: EPZ011989
Purity: ≥98%
Packaging: 500μg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 19161
Product name: EPZ011989
Purity: ≥98%
Packaging: 1mg
Price: $228
Updated: 2024/03/01

Cayman Chemical

Product number: 19161
Product name: EPZ011989
Purity: ≥98%
Packaging: 5mg
Price: $952
Updated: 2024/03/01

TRC

Product number: D450170
Product name: N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-benzamide
Packaging: 25mg
Price: $110
Updated: 2021/12/16

Usbiological

Product number: 474095
Product name: EPZ011989
Packaging: 100mg
Price: $1932
Updated: 2021/12/16

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EPZ011969 Chemical Properties,Usage,Production

Description

The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. EPZ011989 is an orally bioavailable EZH2 inhibitor with K_i values that are less than 3 nM for wild type and Tyr⁶⁴⁶ mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.

Uses

N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-benzamide is used in biological studies as inhibitors of EZH2 histone methyltransferase for the treatment of cancer.

EPZ011969 Preparation Products And Raw materials

Raw materials

Preparation Products

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EPZ011969 Suppliers

China 63 United States 13 Global 76

MedChemexpress LLC

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Target molecule Corp.

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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BOC Sciences

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BOC Sciences

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1598383-40-4, EPZ011969Related Search:

EPZ011969

EPZ011989

N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]benzamide

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-ynyl)benzamide

EPZ011989;EPZ-011989

CS-2079

CS-1609

N-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-3-(ETHYL((TRANS)-4-((2-METHOXYETHYL)(METHYL)AMINO)CYCLOHEXYL)AMINO)-2-METHYL-5-(3-MORPHOLINOPROP-1-YN-1-YL)BENZAMIDE

Benzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-

EPZ011989,inhibit,Histone Methyltransferase,Inhibitor,EPZ 011989,EPZ-011989

1598383-40-4

C35H51N5O4

Inhibitors

API