4-Bromo-2-fluoro-3-methylbenzonitrile

Product Name: 4-Bromo-2-fluoro-3-methylbenzonitrile
CAS No.: 1114546-30-3
Chemical Name: 4-Bromo-2-fluoro-3-methylbenzonitrile
Synonyms: 4-Bromo-2-fluoro-3-methylbenzonitrile;Benzonitrile, 4-bromo-2-fluoro-3-methyl-;4-bromo-2-fluoro-3-methylbenzene-1-carbonitrile
CBNumber: CB52742059
Molecular Formula: C8H5BrFN
Formula Weight: 214.03
MOL File: 1114546-30-3.mol

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4-Bromo-2-fluoro-3-methylbenzonitrile Property

Boiling point:: 259.6±35.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: crystalline powder
color: Wooly, light pinkish peach

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B679505
Product name: 4-Bromo-2-fluoro-3-methylbenzonitrile
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC48590
Product name: 4-Bromo-2-fluoro-3-methylbenzonitrile
Packaging: 250mg
Price: $163
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3737-B-00
Product name: 4-Bromo-2-fluoro-3-methylbenzonitrile
Packaging: 250mg
Price: $192
Updated: 2021/12/16

Apolloscientific

Product number: PC48590
Product name: 4-Bromo-2-fluoro-3-methylbenzonitrile
Packaging: 1g
Price: $378
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3737-B-00
Product name: 4-Bromo-2-fluoro-3-methylbenzonitrile
Packaging: 1g
Price: $448
Updated: 2021/12/16

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4-Bromo-2-fluoro-3-methylbenzonitrile Chemical Properties,Usage,Production

Synthesis

757247-93-1

1114546-30-3

Using 4-amino-2-fluoro-3-methylbenzonitrile (10 g, 66.6 mmol) as starting material, potassium nitrite (22.67 g, 266 mmol) and copper (I) bromide (1.911 g, 13.32 mmol) were dissolved in dimethyl sulfoxide (400 mL). Subsequently, 48% aqueous hydrogen bromide solution (33 mL, 266 mmol) diluted with dimethyl sulfoxide (200 mL) was added dropwise and the reaction mixture was stirred for 2 hours. Upon completion of the reaction, complete conversion of the feedstock was confirmed by thin layer chromatography (TLC) monitoring. The reaction mixture was slowly poured into ice-cold water and neutralized with cold concentrated sodium hydroxide solution to pH 7. The precipitated solid was collected by filtration to afford the target product 4-bromo-2-fluoro-3-methylbenzonitrile (11.4 g, 53.3 mmol, 80% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.47 (d, J = 9.37 Hz, 1H), 7.33 (t, 1H), 2.39 (d, J = 2.34 Hz, 3H).

References

[1] Patent: WO2010/62571, 2010, A1. Location in patent: Page/Page column 128

4-Bromo-2-fluoro-3-methylbenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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1114546-30-3, 4-Bromo-2-fluoro-3-methylbenzonitrileRelated Search:

4-Bromo-2-fluoro-3-methylbenzonitrile

Benzonitrile, 4-bromo-2-fluoro-3-methyl-

4-bromo-2-fluoro-3-methylbenzene-1-carbonitrile

1114546-30-3