N,N-Dimethyl-2-(p-tolyloxy)ethanamine

Product Name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
CAS No.: 51344-14-0
Chemical Name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
Synonyms: Itopride Impurity 12;N,N-Dimethyl-2-(p-tolyloxy)ethanamine;N,N-Dimethyl-2-(4-methylphenoxy)ethanamine;Ethanamine, N,N-dimethyl-2-(4-methylphenoxy)-
CBNumber: CB52743940
Molecular Formula: C11H17NO
Formula Weight: 179.26
MOL File: 51344-14-0.mol

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N,N-Dimethyl-2-(p-tolyloxy)ethanamine Property

storage temp.: Inert atmosphere,Room Temperature

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Safety

HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A681425
Product name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
Purity: 97%
Packaging: 100mg
Price: $13
Updated: 2021/12/16

Ambeed

Product number: A681425
Product name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
Purity: 97%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

Ambeed

Product number: A681425
Product name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
Purity: 97%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Abosyn

Product number: 61-0016
Product name: N,N-dimethyl-2-(p-tolyloxy)ethanamine
Purity: 95-98%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Ambeed

Product number: A681425
Product name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
Purity: 97%
Packaging: 5g
Price: $216
Updated: 2021/12/16

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N,N-Dimethyl-2-(p-tolyloxy)ethanamine Chemical Properties,Usage,Production

Synthesis

106-44-5

4584-46-7

51344-14-0

General procedure for the synthesis of N,N-dimethyl-2-(p-toluyloxy)ethylamine from p-methylphenol and dimethylaminochloroethane hydrochloride: 108 g (1 mol) of p-methylphenol, 61.7 g (1.1 mol) of potassium hydroxide, 200 mL of DMF, and 200 mL of isopropyl ether were added to the reactor. Subsequently 110 g (1.1 mol) of 2-(dimethylamino)chloroethane hydrochloride and 110 g of triethylamine were added. The mixture was stirred and reacted at 80°C for 2 hours. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to recover most of the solvent. The pH of the concentrate was adjusted to 2 with 2 mol-L-1 sulfuric acid and then extracted with 500 mL of chloroform in two portions. The aqueous phase was cooled in ice water, neutralized with 20% sodium hydroxide solution to pH 10, and then extracted with 500 mL ethyl acetate. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to recover the ethyl acetate. Finally, 162.8 g of N,N-dimethyl-2-(p-toluyloxy)ethylamine as a colorless oil was obtained by distillation in 91% yield.

References

[1] Patent: CN106748862, 2017, A. Location in patent: Paragraph 0037; 0053; 0054; 0055; 0056
[2] Patent: CN106748821, 2017, A. Location in patent: Paragraph 0030; 0031; 0032; 0033

N,N-Dimethyl-2-(p-tolyloxy)ethanamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N-Dimethyl-2-(p-tolyloxy)ethanamine Suppliers

China 13 India 1 United States 4 Global 18

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N,N-Dimethyl-2-(p-tolyloxy)ethanamine

Itopride Impurity 12

Ethanamine, N,N-dimethyl-2-(4-methylphenoxy)-

N,N-Dimethyl-2-(4-methylphenoxy)ethanamine

51344-14-0