2-Fluoro-6-nitrobenzoic acid methyl ester

Product Name: 2-Fluoro-6-nitrobenzoic acid methyl ester
CAS No.: 212189-78-1
Chemical Name: 2-Fluoro-6-nitrobenzoic acid methyl ester
Synonyms: Benzoic acid, 2-fluoro-6-nitro-, methyl ester
CBNumber: CB52745151
Molecular Formula: C8H6FNO4
Formula Weight: 199.14
MOL File: 212189-78-1.mol

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2-Fluoro-6-nitrobenzoic acid methyl ester Property

Boiling point:: 282.9±25.0 °C(Predicted)
Density: 1.388±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M706748
Product name: Methyl2-fluoro-6-nitrobenzoate
Packaging: 1mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M706748
Product name: Methyl2-fluoro-6-nitrobenzoate
Packaging: 10mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-3-8D
Product name: Methyl 2-fluoro-6-nitrobenzoate
Packaging: 250mg
Price: $168
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-3-8D
Product name: Methyl 2-fluoro-6-nitrobenzoate
Packaging: 1g
Price: $272
Updated: 2021/12/16

Matrix Scientific

Product number: 083249
Product name: Methyl 2-fluoro-6-nitrobenzoate
Purity: 97%
Packaging: 1g
Price: $414
Updated: 2021/12/16

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2-Fluoro-6-nitrobenzoic acid methyl ester Chemical Properties,Usage,Production

Synthesis

385-02-4

18107-18-1

212189-78-1

General procedure for the synthesis of methyl 2-fluoro-6-nitrobenzoate from 2-fluoro-6-nitrobenzoic acid and trimethylsilylated diazomethane: 2-fluoro-6-nitrobenzoic acid (712 mg, 3.85 mmol) was dissolved in a mixed solvent of methanol/acetonitrile (10 mL/10 mL) under nitrogen protection and cooled to 0 °C. Trimethylsilylated diazomethane solution was slowly added dropwise until the reaction solution took on a persistent yellow color, and stirring was continued at 0 °C for 30 min. Subsequently, the reaction was quenched with glacial acetic acid until the yellow color disappeared. The solvent was partially evaporated under reduced pressure and the residue was dissolved in a small amount of ethyl acetate and purified by fast column chromatography using 30%-50% ethyl acetate/hexane (600 mL) as eluent to afford the target product methyl 2-fluoro-6-nitrobenzoate (716 mg, 94% yield). The product characterization data were as follows: 1H NMR (400 MHz, CDCl3) δ 3.96 (s, 3H), 7.40-7.48 (m, 1H), 7.58 (td, J = 8.31,5.54 Hz, 1H), 7.94 (d, J = 8.31 Hz, 1H); mass spectrometry (MS) m/z 200.05 (MH+), calculated value ( C8H6FNO4) 199.03.

References

[1] Patent: US2006/94707, 2006, A1. Location in patent: Page/Page column 66
[2] Patent: US2007/259850, 2007, A1. Location in patent: Page/Page column 100
[3] Patent: WO2008/51547, 2008, A1. Location in patent: Page/Page column 406

2-Fluoro-6-nitrobenzoic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-6-nitrobenzoic acid methyl ester Suppliers

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212189-78-1, 2-Fluoro-6-nitrobenzoic acid methyl esterRelated Search:

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Benzoic acid, 2-fluoro-6-nitro-, methyl ester

212189-78-1