N-(3-hydroxyphenyl)acrylamide
- Product Name
- N-(3-hydroxyphenyl)acrylamide
- CAS No.
- 13040-21-6
- Chemical Name
- N-(3-hydroxyphenyl)acrylamide
- Synonyms
- 172593;N-tosyl-3-aminophenol;N-(3-hydroxyphenyl)acrylamide;2-Propenamide, N-(3-hydroxyphenyl)-
- CBNumber
- CB52745227
- Molecular Formula
- C9H9NO2
- Formula Weight
- 163.17
- MOL File
- 13040-21-6.mol
N-(3-hydroxyphenyl)acrylamide Property
- Boiling point:
- 382.9±34.0 °C(Predicted)
- Density
- 1.231±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.51±0.10(Predicted)
- Appearance
- off-white solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 7154CB
- Product name
- n-(3-Hydroxyphenyl)acrylamide
- Packaging
- 100mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 7154CB
- Product name
- n-(3-Hydroxyphenyl)acrylamide
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 7154CB
- Product name
- n-(3-Hydroxyphenyl)acrylamide
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
- Product number
- 7154CB
- Product name
- n-(3-Hydroxyphenyl)acrylamide
- Packaging
- 10g
- Price
- $204
- Updated
- 2021/12/16
- Product number
- A224716
- Product name
- N-(3-Hydroxyphenyl)acrylamide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $9
- Updated
- 2021/12/16
N-(3-hydroxyphenyl)acrylamide Chemical Properties,Usage,Production
Synthesis
814-68-6
591-27-5
13040-21-6
The general procedure for the synthesis of 3-acrylamido-phenol from acryloyl chloride and 3-aminophenol is as follows: sodium bicarbonate (5.6 g, 0.067 mol) was added to a mixture of tetrahydrofuran (100 mL) and water (30 mL) of 3-aminophenol (5.0 g, 0.045 mol), followed by a slow dropwise addition of acryloyl chloride (3.6 mL, 0.045 mol) . The reaction mixture was stirred at room temperature for 3.5 hours. After completion of the reaction, dichloromethane was added for extraction and the organic layer was washed with aqueous ammonium chloride. After separation of the organic layer, it was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was recrystallized by a solvent mixture of dichloromethane and ether to give 3-acrylamido-phenol (2.9 g, 40% yield). The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 5.73 (dd, 1H), 6.24 (dd, 1H), 6.42 (m, 2H), 7.04 (m, 2H), 7.24 (s, 1H), 9.39 (s, 1H), 9.97 (s, 1H).
References
[1] Patent: WO2013/100631, 2013, A1. Location in patent: Page/Page column 13; 15-16
[2] Patent: EP2058318, 2009, A1
[3] European Journal of Medicinal Chemistry, 2017, vol. 133, p. 329 - 339
[4] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 10, p. 2724 - 2729
[5] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 60 - 69
N-(3-hydroxyphenyl)acrylamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(3-hydroxyphenyl)acrylamide manufacturers
- Product
- N-(3-hydroxyphenyl)acrylamide 13040-21-6
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10