4-Chloro-5-fluoro-2-hydroxy-benzaldehyde

Product Name: 4-Chloro-5-fluoro-2-hydroxy-benzaldehyde
CAS No.: 1205551-36-5
Chemical Name: 4-Chloro-5-fluoro-2-hydroxy-benzaldehyde
Synonyms: 4-chloro-5-fluoro-2-hydroxybenzladehyde;4-Chloro-5-fluoro-2-hydroxy-benzaldehyde;Benzaldehyde, 4-chloro-5-fluoro-2-hydroxy-
CBNumber: CB52746486
Molecular Formula: C7H4ClFO2
Formula Weight: 174.56
MOL File: 1205551-36-5.mol

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4-Chloro-5-fluoro-2-hydroxy-benzaldehyde Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to yellow Solid

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Safety

HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 2615-7-37
Product name: 4-Chloro-5-fluoro-2-hydroxybenzaldehyde
Purity: 96%
Packaging: 250mg
Price: $149
Updated: 2021/12/16

Apolloscientific

Product number: PC909159
Product name: 4-Chloro-5-fluoro-2-hydroxybenzaldehyde
Purity: 97%
Packaging: 250mg
Price: $93
Updated: 2021/12/16

AK Scientific

Product number: 2773AJ
Product name: 4-Chloro-5-fluoro-2-hydroxy-benzaldehyde
Packaging: 5g
Price: $1265
Updated: 2021/12/16

Crysdot

Product number: CD12174012
Product name: 4-Chloro-5-fluoro-2-hydroxybenzaldehyde
Purity: 97%
Packaging: 10g
Price: $1386
Updated: 2021/12/16

Ambeed

Product number: A219416
Product name: 4-Chloro-5-fluoro-2-hydroxybenzaldehyde
Purity: 97%
Packaging: 10g
Price: $1454
Updated: 2021/12/16

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4-Chloro-5-fluoro-2-hydroxy-benzaldehyde Chemical Properties,Usage,Production

Synthesis

100-97-0

2613-23-2

1205551-36-5

The general procedure for the synthesis of 4-chloro-5-fluoro-2-hydroxybenzaldehyde from hexamethylenetetetramine (210 g, 1.5 mol) and 3-chloro-4-fluorophenol (210 g, 1.43 mol) was as follows: hexamethylenetetetramine was added to trifluoroacetic acid (3.6 L) in small portions, and the resulting mixture was heated to reflux at 78 °C. Subsequently, a solution of 3-chloro-4-fluorophenol in trifluoroacetic acid (1.4 L) was slowly added dropwise, and stirring of the reaction mixture was continued for 1 hour after completion of the addition. After completion of the reaction, the mixture was cooled to room temperature and concentrated under vacuum. The concentrated residue was poured into ice water (2 L) and stirred overnight. The mixture was filtered, the filter cake was collected and dissolved in ethyl acetate (500 mL), dried with magnesium sulfate and concentrated again under vacuum. The crude product was washed with a solvent mixture of ethyl acetate/petroleum ether (10:1, v/v) to give the final 4-chloro-5-fluoro-2-hydroxybenzaldehyde as a white solid with a yield of 56.5 g in 23%. The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts of δ = 7.00-7.01 (m, 1H), 7.19-7.26 (m, 1H), 9.75 (s, 1H), 10.82 (s, 1H) ppm.

References

[1] Patent: US2010/16366, 2010, A1. Location in patent: Page/Page column 14
[2] Patent: WO2010/7561, 2010, A1. Location in patent: Page/Page column 26-27

4-Chloro-5-fluoro-2-hydroxy-benzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-5-fluoro-2-hydroxy-benzaldehyde Suppliers

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1205551-36-5, 4-Chloro-5-fluoro-2-hydroxy-benzaldehydeRelated Search:

4-Chloro-5-fluoro-2-hydroxy-benzaldehyde

Benzaldehyde, 4-chloro-5-fluoro-2-hydroxy-

4-chloro-5-fluoro-2-hydroxybenzladehyde

1205551-36-5