1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea

ChemicalBook > CAS DataBase List > 1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea

1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea

Product Name: 1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea
CAS No.: 508186-14-9
Chemical Name: 1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea
Synonyms: Ac-COA Synthase Inhibitor;ACSS;MDK-6149;INVIVO-6149;Ac-CoA Synthase Inhibitor1;Acetyl-CoA Synthase Inhibitor;ACSS2 INHIBITOR;AC-COA SYNTHASE INHIBITOR;1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2...;Urea, N-(2,3-di-2-thienyl-6-quinoxalinyl)-N'-(2-methoxyethyl)-;1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea
CBNumber: CB52748086
Molecular Formula: C20H18N4O2S2
Formula Weight: 410.51
MOL File: 508186-14-9.mol

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1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea Property

Boiling point:: 539.3±50.0 °C(Predicted)
Density: 1.364±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 12.34±0.43(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.33756
Product name: Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem
Packaging: 25MG
Price: $223
Updated: 2023/01/07

ChemScene

Product number: CS-7715
Product name: Ac-CoASynthaseInhibitor1
Purity: 99.23%
Packaging: 25mg
Price: $228
Updated: 2021/12/16

ChemScene

Product number: CS-7715
Product name: Ac-CoASynthaseInhibitor1
Purity: 99.23%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-7715
Product name: Ac-CoASynthaseInhibitor1
Purity: 99.23%
Packaging: 10mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-7715
Product name: Ac-CoASynthaseInhibitor1
Purity: 99.23%
Packaging: 50mg
Price: $396
Updated: 2021/12/16

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1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea Chemical Properties,Usage,Production

Uses

Ac-CoA Synthase Inhibitor can be prepared for the treatment of Compositions for neurological and cognitive diseases and disorders, particularly useful in the treatment of anxiety disorders and disorders such as phobias, panic disorders, psychosocial stress (such as seen in disasters, disasters or victims of violence), obsessive-compulsive disorders, generalized Anxiety disorders and post-traumatic stress disorder (PTSD).Also it may be used to modulate long-term memory storage or consolidation, to treat addiction and/or addiction-related diseases or conditions, to prevent or treat acute alcohol-induced memory Deficits and chronic alcohol-induced memory deficits.

Biological Activity

Ac-CoA Synthase Inhibitor is a potent and specific inhibitor of acetyl-CoA synthase 2 (ACSS2). It also inhibits respiratory syncytial virus (RSV).

in vitro

Ac-CoA Synthase Inhibitor inhibits the incorporation of [14C]acetate into lipids in HepG2 cells with IC50 of 6.8 μM. It inhibits histone acetylation by [14C]acetate in HepG2 cells with IC50 of 5.5 μM.

target

Target	Value
ACSS2 (Cell-free assay)	~0.6 μM

1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

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508186-14-9, 1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)ureaRelated Search:

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