ChemicalBook > CAS DataBase List > INDY

INDY

Product Name
INDY
CAS No.
1169755-45-6
Chemical Name
INDY
Synonyms
INDY;CID 69538603;INDY, DYRK1A/B inhibitor;(1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone;(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone;(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one;(Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-
CBNumber
CB52748091
Molecular Formula
C12H13NO2S
Formula Weight
235.3
MOL File
1169755-45-6.mol
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INDY Property

Boiling point:
409.2±45.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
pka
9.67±0.20(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1011
Product name
INDY
Purity
≥98% (HPLC)
Packaging
5mg
Price
$103
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1011
Product name
INDY
Purity
≥98% (HPLC)
Packaging
25mg
Price
$334
Updated
2024/03/01
Cayman Chemical
Product number
23895
Product name
INDY
Purity
≥98%
Packaging
1mg
Price
$30
Updated
2024/03/01
Cayman Chemical
Product number
23895
Product name
INDY
Purity
≥98%
Packaging
5mg
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
23895
Product name
INDY
Purity
≥98%
Packaging
10mg
Price
$134
Updated
2024/03/01
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INDY Chemical Properties,Usage,Production

Description

INDY is an ATP-competitive inhibitor of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A; Ki = 180 nM; IC50 = 240 nM). It is selective for DYRK1A over monoamine oxidase (MAO) A and B at concentrations up to 100 μM. INDY inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner. It also restores signaling through nuclear factory of activated T cells (NFAT) and NFAT-dependent transcription in HEK293 cells overexpressing DYRK1A. In vivo, INDY reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos. INDY also induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro.

Uses

INDY is a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A/B (DYRK1A/B) inhibitor (1,2).

storage

-20°C

INDY Preparation Products And Raw materials

Raw materials

Preparation Products

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INDY Suppliers

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1169755-45-6, INDYRelated Search:


  • INDY
  • (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
  • (1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone
  • (1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
  • 2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-
  • (Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
  • CID 69538603
  • INDY, DYRK1A/B inhibitor
  • 1169755-45-6