ChemicalBook > CAS DataBase List > 1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea

1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea

Product Name: 1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea
CAS No.: 1370256-78-2
Chemical Name: 1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea
Synonyms: CS-2113;SKLB477;AOB5016;SKLB4771;FLT3-IN-1;CHEMBL2046883;FLT3-IN-1, >98%;SKLB 4771;SKLB-4771;FLT3-IN-1(SKLB4771);SKLB4771 (FLT3-IN-1)
CBNumber: CB52749098
Molecular Formula: C25H27N7O3S2
Formula Weight: 537.66
MOL File: 1370256-78-2.mol

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1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea Property

Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 47 mg/mL (87.42 mM)
form: Solid
pka: 6.62±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4280
Product name: SKLB4771
Purity: >98.0%
Packaging: 5mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-4280
Product name: SKLB4771
Purity: >98.0%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-4280
Product name: SKLB4771
Purity: >98.0%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-4280
Product name: SKLB4771
Purity: >98.0%
Packaging: 100mg
Price: $1400
Updated: 2021/12/16

Crysdot

Product number: CD31003718
Product name: FLT3-IN-1
Purity: 98+%
Packaging: 100mg
Price: $1470
Updated: 2021/12/16

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1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea Chemical Properties,Usage,Production

Uses

FLT3-IN-1, is a FLT3 inhibitor.

in vivo

SKLB4771 (20-100 mg/kg; i.p.; once daily; 21 d) inhibits tumor growth in vivo without significant weight loss or any other obvious signs of toxicity on mice^[1].
Pharmacokinetic Analysis of SKLB4771 in rat (40 mg/kg; i.p.)^[1]

C_max (μg/mL)	T_1/2 (h)	AUC_max (h·μg/mL)	T_max (h)	CL_obs (L/h/kg)
5.31	13.9	21.86	1.0	2.21

Animal Model:	Female NOD-SCID mouse (6?7 weeks old)^[1]
Dosage:	20, 40, 100 mg/kg; dissolved in 25% (v/v) PEG400 plus 5% DMSO, administered at a dose of 5 mL/kg
Administration:	Intraperitoneal injection; once daily; 21 days
Result:	Inhibited tumor growth by 66% and 84% at concentration of 20 mg/kg and 40 mg/kg, respectively. Resulted cell proliferation inhibition and apoptosis induction.

1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea Suppliers

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1370256-78-2, 1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylureaRelated Search:

1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea

FLT3-IN-1

N-(4-Methylphenyl)-N'-[5-[[7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]thio]-1,3,4-thiadiazol-2-yl]urea

SKLB4771

AOB5016

CHEMBL2046883

SKLB477

SKLB 4771;SKLB-4771

CS-2113

FLT3-IN-1, >98%

Urea, N-(4-methylphenyl)-N'-[5-[[7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]thio]-1,3,4-thiadiazol-2-yl]-

FLT3-IN-1(SKLB4771)

inhibit,cell proliferation inhibition,selective,c-Kit,Inhibitor,SKLB4771,SKLB-4771,Cluster of differentiation antigen 135,FLT3,CD135,SKLB 4771,Fms like tyrosine kinase 3,apoptosis induction,phosphorylation,CD117,SCFR

SKLB4771 (FLT3-IN-1)

1-(5-((7-(3-Morpholinopropoxy)quinazolin-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-(p-tolyl)urea , SKLB4771

SKLB4771, 10 mM in DMSO

1370256-78-2

C25H27N7O3S2

Inhibitors