ChemicalBook > CAS DataBase List > 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide

1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide

Product Name
1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
CAS No.
403718-45-6
Chemical Name
1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
Synonyms
Qc1;Threonine Dehydrogenase Inhibitor, QC1;Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem;N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide;1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide;7-Quinazolinecarboxamide, 1,2,3,4-tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-
CBNumber
CB52750492
Molecular Formula
C23H16F3N3O2S
Formula Weight
455.45
MOL File
403718-45-6.mol
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1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide Property

Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL (clear solution, warmed)
pka
10.13±0.20(Predicted)
form 
White powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0481
Product name
Qc1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$134
Updated
2025/07/31
Sigma-Aldrich
Product number
603425
Product name
Threonine Dehydrogenase Inhibitor, QC1
Packaging
10mg
Price
$223
Updated
2023/01/07
Sigma-Aldrich
Product number
SML0481
Product name
Qc1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$465
Updated
2022/05/15
Tocris
Product number
5055
Product name
Qc1
Purity
≥98%(HPLC)
Packaging
10
Price
$162
Updated
2021/12/16
Tocris
Product number
5055
Product name
Qc1
Purity
≥98%(HPLC)
Packaging
50
Price
$679
Updated
2021/12/16
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1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide Chemical Properties,Usage,Production

Uses

Qc 1 is used in the preparation of bis(benzylcarbamoyl)methylthio dihydroquinazolinones.

Biological Activity

Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). The IC50 value for inhibition of TDH by Qc1 is 500 nM, with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. Qc1 induces arrest and autophagy of mouse ES cells with an EC50 of 3 mM.

1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide Suppliers

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403718-45-6, 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamideRelated Search:


  • 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
  • Qc1
  • Threonine Dehydrogenase Inhibitor, QC1
  • Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem
  • 7-Quinazolinecarboxamide, 1,2,3,4-tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-
  • N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
  • 403718-45-6