2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine

Product Name: 2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine
CAS No.: 313669-88-4
Chemical Name: 2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine
Synonyms: BMS-986122;BMS-986122 ，E0472;BMS-986122 >=98% (HPLC);BMS-986122, 10 mM in DMSO;2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine;Thiazolidine, 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-;positive,BMS986122,modulator,allosteric,recruitment,β-arrestin,adenylyl,Opioid Receptor,BMS-986122,inhibit,cyclase,Inhibitor,protein
CBNumber: CB52750513
Molecular Formula: C16H15BrClNO3S2
Formula Weight: 448.78
MOL File: 313669-88-4.mol

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2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Property

Boiling point:: 567.2±60.0 °C(Predicted)
Density: 1.586±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: -8.81±0.40(Predicted)
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0917
Product name: BMS-986122
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $144
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0917
Product name: BMS-986122
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $552
Updated: 2025/07/31

Cayman Chemical

Product number: 23269
Product name: BMS 986122
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 23269
Product name: BMS 986122
Purity: ≥98%
Packaging: 5mg
Price: $227
Updated: 2024/03/01

AK Scientific

Product number: 0461CN
Product name: 2-(3-Bromo-4-methoxyphenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine
Packaging: 1mg
Price: $152
Updated: 2021/12/16

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2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Chemical Properties,Usage,Production

Uses

BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (μ-OR). BMS-986122 shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes[1][2].

Biochem/physiol Actions

BMS-986122 may exhibit an antinociception effect in vivo by increasing the efficiency of Met-enkephalin (met-Enk) to inhibit γ aminobutyric acid (GABA) release in the periaqueductal gray region of the brain.

IC 50

μ Opioid Receptor/MOR

References

[1] Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc Natl Acad Sci U S A. 2013;110(26):10830-10835. DOI:10.1073/pnas.1300393110
[2] Kandasamy R, et al. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proc Natl Acad Sci U S A. 2021;118(16):e2000017118. DOI:10.1073/pnas.2000017118
[3] Livingston KE, Alt A, Canals M, Traynor JR. Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors. Mol Pharmacol. 2018;93(2):157-167. DOI:10.1124/mol.117.109561

2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine Suppliers

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313669-88-4, 2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidineRelated Search:

2-(3-Bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine

BMS-986122

Thiazolidine, 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-

BMS-986122 >=98% (HPLC)

positive,BMS986122,modulator,allosteric,recruitment,β-arrestin,adenylyl,Opioid Receptor,BMS-986122,inhibit,cyclase,Inhibitor,protein

BMS-986122, 10 mM in DMSO

BMS-986122 ，E0472

313669-88-4