BC-1258

Product Name: BC-1258
CAS No.: 1507370-40-2
Chemical Name: BC-1258
Synonyms: BC-1258;N1,N2-Bis(4-(thiazol-2-yl)benzyl)ethane-1,2-diamine;N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-;N,N'-bis[[4-(1,3-thiazol-2-yl)phenyl]methyl]ethane-1,2-diamine;LRR,F-box,inhibit,repeat,BC-?1258,BC ?1258,FBXL2,Apoptosis,tumor,Inhibitor,BC?1258;LRR|||F-box|||BC1258|||inhibit|||repeat|||BC-1258|||BC-1258|||BC-?1258|||BC ?1258|||FBXL2|||Apoptosis|||BC-1258|||tumor|||Inhibitor|||BC?1258|||BC 1258
CBNumber: CB52750609
Molecular Formula: C22H22N4S2
Formula Weight: 406.57
MOL File: 1507370-40-2.mol

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BC-1258 Property

storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear (warmed)
form: powder
color: white to beige
InChI: InChI=1S/C22H22N4S2/c1-5-19(21-25-11-13-27-21)6-2-17(1)15-23-9-10-24-16-18-3-7-20(8-4-18)22-26-12-14-28-22/h1-8,11-14,23-24H,9-10,15-16H2
InChIKey: FRTSLZJCGAFSET-UHFFFAOYSA-N
SMILES: C(NCC1=CC=C(C2=NC=CS2)C=C1)CNCC1=CC=C(C2=NC=CS2)C=C1

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1021
Product name: BC-1258
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1021
Product name: BC-1258
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $423
Updated: 2022/05/15

AK Scientific

Product number: SYN5045
Product name: BC-1258
Packaging: 100mg
Price: $830
Updated: 2021/12/16

DC Chemicals

Product number: DC43054
Product name: BC-1258
Purity: >98%
Packaging: 1g
Price: $1600
Updated: 2021/12/16

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BC-1258 Chemical Properties,Usage,Production

Description

BC-1258 (N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine) is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. BC-1258 induces mitotic arrest and apoptosis of tumorigenic cells. Also BC-1258 inhibits tumor formation in athymic nude mice.

Mechanism of action

BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator that stabilized and increased levels of FBXL2 protein that promoted Aurora B degradation, resulting in tetraploidy, mitotic arrest and apoptosis of tumorigenic cells, and profoundly inhibiting tumor formation in athymic nude mice. It is sufficient to stabilize and upregulate FBXL2 levels, and, when administered in vivo, prematurely depletes Aurora B by SCFFBXL2-induced ubiquitination and degradation, leading to cell death and inhibiting growth of human leukemic cells in a xenograft model[1].

References

[1] B B Chen. “Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis.” Cell Death & Disease (2013): e759.

BC-1258 Preparation Products And Raw materials

Raw materials

Preparation Products

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BC-1258 Suppliers

China 26 United Kingdom 1 United States 3 Global 30

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1507370-40-2, BC-1258Related Search:

N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine

BC-1258

N,N'-bis[[4-(1,3-thiazol-2-yl)phenyl]methyl]ethane-1,2-diamine

1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-

LRR,F-box,inhibit,repeat,BC-?1258,BC ?1258,FBXL2,Apoptosis,tumor,Inhibitor,BC?1258

N1,N2-Bis(4-(thiazol-2-yl)benzyl)ethane-1,2-diamine

LRR|||F-box|||BC1258|||inhibit|||repeat|||BC-1258|||BC-1258|||BC-?1258|||BC ?1258|||FBXL2|||Apoptosis|||BC-1258|||tumor|||Inhibitor|||BC?1258|||BC 1258

1507370-40-2