3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide

Product Name: 3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide
CAS No.: 1235397-05-3
Chemical Name: 3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide
Synonyms: PF4856264;PF 4856264;PF-4856264;PF-04856264;PF 04856264,PF04856264;PF-04856264 >=98% (HPLC);3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide;Benzenesulfonamide, 3-cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-;3-cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide;3-CYANO-4-(2-(1-METHYL-1H-PYRAZOL-5-YL) PHENOXY)-N-(THIAZOL-2-YL) BENZENESULFONAMIDE
CBNumber: CB52750715
Molecular Formula: C20H15N5O3S2
Formula Weight: 437.49
MOL File: 1235397-05-3.mol

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3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide Property

Boiling point:: 635.0±65.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 5.68±0.10(Predicted)
form: powder
color: white to light brown

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1061
Product name: PF-04856264
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $137
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1061
Product name: PF-04856264
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $546
Updated: 2025/07/31

ChemScene

Product number: CS-0012528
Product name: PF-04856264
Purity: ≥99.0%
Packaging: 5mg
Price: $504
Updated: 2021/12/16

Chemenu

Product number: CM331018
Product name: 3-cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide
Purity: 95%+
Packaging: 100mg
Price: $582
Updated: 2021/12/16

Chemenu

Product number: CM331018
Product name: 3-cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide
Purity: 95%+
Packaging: 250mg
Price: $965
Updated: 2021/12/16

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3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide Chemical Properties,Usage,Production

Uses

PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect[1][2].

Biochem/physiol Actions

PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC50 = 28 nM). PF-04856264 blocks mouse Nav1.7 (IC50 = 131 nM) but has low potency against the rat Nav1.7 channel (IC50 = 4.2 mM).

in vivo

PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors^[2].

Animal Model:	6-8 weeks adult male C57BL/6J mice (OD1-induced spontaneous pain model)^[2]
Dosage:	3, 30 mg/kg
Administration:	I.p.
Result:	Significantly reduced spontaneous pain behaviors in mice.

IC 50

Nav1.7

References

[1] McCormack K, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2013;110(29):E2724-E2732. DOI:10.1073/pnas.1220844110
[2] Deuis JR, et al. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016;8(3):78. Published 2016 Mar 17. DOI:10.3390/toxins8030078

3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide Suppliers

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1235397-05-3, 3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamideRelated Search:

3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide

PF-04856264

3-cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide

3-CYANO-4-(2-(1-METHYL-1H-PYRAZOL-5-YL) PHENOXY)-N-(THIAZOL-2-YL) BENZENESULFONAMIDE

PF-04856264 >=98% (HPLC)

PF 4856264

PF4856264

PF-4856264

PF 04856264,PF04856264

Benzenesulfonamide, 3-cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-

1235397-05-3