5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide

Product Name: 5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide
CAS No.: 1245626-05-4
Chemical Name: 5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide
Synonyms: AM6545;AM-6545,AM6545;5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide;5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, 5-[4-(4-cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-
CBNumber: CB52750957
Molecular Formula: C26H23Cl2N5O3S
Formula Weight: 556.46
MOL File: 1245626-05-4.mol

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5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide Property

storage temp.: 2-8°C
solubility: DMSO: >25mg/mL
form: powder
color: white to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A1987
Product name: AM6545
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $276
Updated: 2024/03/01

Sigma-Aldrich

Product number: A1987
Product name: AM6545
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $878
Updated: 2024/03/01

Cayman Chemical

Product number: 16316
Product name: AM6545
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16316
Product name: AM6545
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 16316
Product name: AM6545
Purity: ≥98%
Packaging: 10mg
Price: $235
Updated: 2024/03/01

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5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide Chemical Properties,Usage,Production

Uses

AM 6545 is a novel CB1 antagonist which suppresses food intake and food-motivated behaviours. Potential for use as an appetite suppressant.

Biological Activity

AM6545 helps in decreasing the development of albuminuria, inflammation and expression of markers of fibrosis. It also helps in the down-regulation of nephrin and podocin. It has the ability to repress the ingestion of food and food-reinforced behaviour.', 'AM6545 is a peripheral CB1 cannabinoid receptor antagonist and appetite suppressant.

in vivo

AM6545 (5-20 mg/kg; i.p.; once daily; 7 days or single dose) reduces food intake and sustaines body weight in Sprague Dawley rats at 10 and 20 mg/kg when treated chronically or acutely^[1].
AM6545 (10 mg/kg; ip; single dose) treatment of C57BL/6 J mice specifically induces PKA signaling activation in adipose tissue and upregulated Akt-mTOR and ERK phosphorylation levels^[2].

AM6545 (10 mg/kg; i.p.; once daily; 4 weeks) significantly improves renal function, inhibited proteinuria, uric acid excretion and renal fibrosis in a rat model of metabolic syndrome^[3].

Animal Model:	Sprague Dawley rats (male, 250-275 g; normal/high-fat diet models)^[1]
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg (4% DMSO, 1% Tween 80 in saline)
Administration:	Intraperitoneal injection, daily for 7 days or single dose.
Result:	Reduced food intake (30% inhibition at 3 h) and body weight gain (days 4-7) at 10 mg/kg dose, without inducing conditioned taste avoidance or gaping.

Animal Model:	Metabolic syndrome rats (male, Wistar; high-fructose/high-salt diet-induced)^[3]
Dosage:	10 mg/kg (0.5% carboxymethylcellulose)
Administration:	Intraperitoneal injection, daily for 4 weeks
Result:	Reduced proteinuria (50%) and urinary uric acid (attenuated 10-fold increase), alleviated glomerular hypertrophy, tubular injury, and collagen deposition, and suppressed renal TGFβ1 expression.

Animal Model:	C57BL/6 mice (male, 18.5-21.0 g; normal diet)^[2]
Dosage:	10 mg/kg (4% DMSO, 10% Tween 80, 80-95% saline)
Administration:	Intraperitoneal injection, single.
Result:	Significantly modified p-PKA substrates in adipose and liver tissue, but the responsive substrates are tissue-specific and remain to be determined Upregulated ERK1 phosphorylation at Thr202 in WAT, liver, TA. Upregulated p-Akt(Ser473) and p-mTOR(Ser2448) in liver.

storage

Store at +4°C

5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide Suppliers

Canada 1 China 29 India 1 United Kingdom 1 United States 7 USA 1 Global 40

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1245626-05-4, 5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamideRelated Search:

5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide

5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide

AM6545

1H-Pyrazole-3-carboxamide, 5-[4-(4-cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-

AM-6545,AM6545

1245626-05-4

C26H23Cl2N5O3S